Developing new metal-based therapeutics: challenges and opportunities

被引：285
作者：
Hambley, Trevor W. [1 ]
机构：
[1] Univ Sydney, Sch Chem, Ctr Heavy Met Res, Sydney, NSW 2006, Australia
来源：
DALTON TRANSACTIONS | 2007年 / 43期
关键词：
D O I：
10.1039/b706075k
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Unexpected side effects and problems experienced in clinical trials have created a difficult environment for those developing new pharmaceuticals and, as a consequence, the number of new chemical entities being registered has fallen to a historic low. Those developing metal-based therapeutics will face the same difficulties, but this environment also provides many opportunities for creative solutions to be applied to overcoming the problems and concerns. In this perspective, these challenges and opportunities are considered in the context of examples of a number of classes of metal-based therapeutics.
引用
收藏
页码：4929 / 4937
页数：9
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