Synthesis and Evaluation of Artificial DNA Scissors: An Interdisciplinary Undergraduate Experiment

被引：10

作者：

Hormann, Jan ^{[1
]}

Streller, Sabine ^{[2
]}

Kulak, Nora ^{[1
]}

机构：

[1] Free Univ Berlin, Inst Chem & Biochem, Anorgan Chem, D-14195 Berlin, Germany

[2] Free Univ Berlin, Inst Chem & Biochem, Didakt Chem, D-14195 Berlin, Germany

来源：

JOURNAL OF CHEMICAL EDUCATION | 2018年 / 95卷 / 10期

关键词：

Upper-Division Undergraduate; Interdisciplinary/Multidisciplinary; Synthesis; Coordination Compounds; Molecular Biology; Nucleic Acids/DNA/RNA; Bioinorganic Chemistry; CHEMISTRY;

D O I：

10.1021/acs.jchemed.7b00662

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bridging organic and inorganic chemistry as well as molecular biology, this undergraduate experiment deals with the synthesis of ligands for metal complexes that can cleave DNA. Students gain theoretical and experimental expertise about metal-DNA interactions and the mechanisms behind DNA cleavage. This experiment lays a basis for the understanding and the rational design of artificial DNA scissors and provides insight into interdisciplinary research in the field of bioinorganic chemistry.

引用

页码：1848 / 1855

页数：8

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