A Multispecies Cluster of VIM-1 Carbapenemase-Producing Enterobacterales Linked by a Novel, Highly Conjugative, and Broad-Host-Range IncA Plasmid Forebodes the Reemergence of VIM-1

被引：24

作者：

Arcari, Gabriele ^{[1
]}

Di Lella, Federica Maria ^{[2
]}

Bibbolino, Giulia ^{[3
]}

Mengoni, Fabio ^{[4
]}

Beccaccioli, Marzia ^{[5
]}

Antonelli, Guido ^{[1
]}

Faino, Luigi ^{[5
]}

Carattoli, Alessandra ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Mol Med, Rome, Italy

[2] Univ Campania Luigi Vanvitelli, Dept Expt Med, Naples, Italy

[3] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, Naples, Italy

[4] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, Rome, Italy

[5] Sapienza Univ Rome, Dept Environm Biol, Rome, Italy

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2020年 / 64卷 / 04期

关键词：

antibiotic resistance; carbapenems; hospital infections; metallo-beta-lactamases; plasmid-mediated resistance; BETA-LACTAMASE GENE; KLEBSIELLA-PNEUMONIAE; R FACTORS; RESISTANCE; BLA(VIM-1); COMPATIBILITY; EPIDEMIOLOGY; EVOLUTION; SEQUENCE; SPREAD;

D O I：

10.1128/AAC.02435-19

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this study, we investigated VIM-1-producing Escherichia colt, Klebsiella oxytoca, Klebsiella pneumoniae, Citrobacter freundii, and Enterobacter cloacae strains, isolated in 2019 during a period of active surveillance of carbapenem-resistant Enterobacterales in a large university hospital in Italy. VIM-1-producing strains colonized the gut of patients, with up to three different VIM-1-positive bacterial species isolated from a single rectal swab, but also caused bloodstream infection in one colonized patient. In the multispecies cluster, bla(VIM-1) was identified in a 5-gene cassette class 1 integron, associated with several genetic determinants, including the bla(SHV-12), qnrS1, and mph(A) genes, located on a highly conjugative and broad-host-range IncA plasmid. The characteristics and origin of this IncA plasmid were studied.

引用

页数：11

共 30 条

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