Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma

被引：28
作者：
Ohmura, Shunya [1 ,2 ,3 ,4 ]
Marchetto, Aruna [4 ]
Orth, Martin F. [4 ]
Li, Jing [1 ,2 ,3 ]
Jabar, Susanne [5 ,6 ]
Ranft, Andreas [5 ,6 ]
Vinca, Endrit [1 ,2 ,3 ]
Ceranski, Katharina [1 ,2 ,3 ]
Carreno-Gonzalez, Martha J. [1 ,2 ,3 ]
Romero-Perez, Laura [1 ,2 ,3 ,4 ]
Wehweck, Fabienne S. [4 ]
Musa, Julian [1 ,2 ,3 ,4 ,7 ]
Bestvater, Felix [8 ]
Knott, Maximilian M. L. [4 ]
Hoelting, Tilman L. B. [4 ]
Hartmann, Wolfgang [9 ]
Dirksen, Uta [5 ,6 ]
Kirchner, Thomas [10 ,11 ]
Cidre-Aranaz, Florencia [1 ,2 ,3 ,4 ]
Grunewald, Thomas G. P. [1 ,2 ,3 ,4 ,12 ]
机构：
[1] Hopp Childrens Canc Ctr Heidelberg KiTZ, Heidelberg, Germany
[2] German Canc Res Ctr, Div Translat Pediat Sarcoma Res B410, Neuenheimer Feld 280, D-69210 Heidelberg, Germany
[3] Hopp Childrens Canc Ctr KiTZ, Neuenheimer Feld 280, D-69210 Heidelberg, Germany
[4] Ludwig Maximilians Univ Munchen, Inst Pathol, Fac Med, Max Eder Res Grp Pediat Sarcoma Biol, Munich, Germany
[5] Univ Hosp Essen, West German Canc Ctr, Pediat 3, Essen, Germany
[6] German Canc Consortium DKTK, Partner Site Essen, Essen, Germany
[7] Heidelberg Univ Hosp, Dept Gen Visceral & Transplantat Surg, Heidelberg, Germany
[8] German Canc Consortium DKTK, Light Microscopy Facil, German Canc Res Ctr DKFZ, Heidelberg, Germany
[9] Univ Hosp Munster, Gerhard Domagk Inst Pathol, Div Translat Pathol, Munster, Germany
[10] Ludwig Maximilians Univ Munchen, Inst Pathol, Fac Med, Munich, Germany
[11] German Canc Consortium DKTK, Partner Site Munich, Munich, Germany
[12] Heidelberg Univ Hosp, Inst Pathol, Heidelberg, Germany
来源：
MOLECULAR CANCER | 2021年 / 20卷 / 01期
关键词：
Ewing sarcoma; RRM2; Targeted therapy; Prognostic biomarker; Paediatric oncology; Triapine; Chemoresistance; RIBONUCLEOTIDE REDUCTASE INHIBITOR; GTI-2040 PLUS DOCETAXEL; 3-AMINOPYRIDINE-2-CARBOXALDEHYDE THIOSEMICARBAZONE; PHASE-I/II; MANAGEMENT; RECURRENCE;
D O I：
10.1186/s12943-021-01393-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页数：7
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