Chemoprevention of colon cancer by calcium, vitamin D and folate: Molecular mechanisms

被引：428
作者：
Lamprecht, SA
Lipkin, M
机构：
[1] Rockefeller Univ, Strang Canc Prevent Ctr, New York, NY 10021 USA
[2] Rockefeller Univ, Strang Canc Res Lab, New York, NY 10021 USA
来源：
NATURE REVIEWS CANCER | 2003年 / 3卷 / 08期
关键词：
D O I：
10.1038/nrc1144
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent findings have indicated that dietary calcium, vitamin D and folate can modulate and inhibit colon carcinogenesis. Supporting evidence has been obtained from a wide variety of preclinical experimental studies, epidemiological findings and a few human clinical trials. Important molecular events and cellular actions of these micronutrients that contribute to their tumour-modulating effects are discussed. They include a complex series of signalling events that affect the structural and functional organization of colon cells.
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收藏
页码：601 / 614
页数：14
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