Breast Cancer Surgery-Induced Immunomodulation

被引：26

作者：

Boomsma, Martijn F. ^{[1
]}

Garssen, Bert ^{[1
]}

Slot, Edith ^{[2
]}

Berbee, Monique ^{[3
]}

Berkhof, Johannes ^{[4
]}

Meezenbroek, Eltica De Jager ^{[1
]}

Slieker, Walentina ^{[5
]}

Visser, Adriaan ^{[6
]}

Meijer, Sybren ^{[7
]}

Beelen, Robert H. J. ^{[2
]}

机构：

[1] Helen Dowling Inst, Ctr Psychooncol, NL-3582 JJ Utrecht, Netherlands

[2] Vrije Univ Amsterdam Med Ctr, Dept Cell Biol & Immunol, Amsterdam, Netherlands

[3] Med Ctr Alkmaar, Dept Surg, Alkmaar, Netherlands

[4] Vrije Univ Amsterdam Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands

[5] Med Ctr Alkmaar, Lab Clin Chem Haematol & Immunol, Alkmaar, Netherlands

[6] Rotterdam Univ, Inst Hlth Care, Expertise Ctr Transit Care, Rotterdam, Netherlands

[7] Vrije Univ Amsterdam Med Ctr, Dept Surg Oncol, Amsterdam, Netherlands

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2010年 / 102卷 / 06期

关键词：

cortisol; cytotoxicity; cytokines; POLYADENYLIC-POLYURIDYLIC ACID; SYSTEMIC IMMUNE-RESPONSE; ACUTE-PHASE RESPONSE; C-REACTIVE PROTEIN; ABDOMINAL-SURGERY; TUMOR-METASTASIS; IN-VITRO; STRESS; INTERVENTION; RECURRENCE;

D O I：

10.1002/jso.21662

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and objectives: Surgical procedures can cause tumor cells to disseminate into the circulatory system Although this spread of metastatic cells will be limited by immune activity. Immunosuppression tends to be the main effect resulting from surgery The objective of this study is to assess hormonal and immunological changes induced by breast cancer surgery Methods: Endocrine and immune responses to surgery were determined in 27 breast cancer patients Blood samples were taken at 6 days and 1 day before surgery and 2 hr. I day. and 5 days after surgery Changes in endocrine function, number of leucocytes and their subpopulations. enumerative immune expression. functional activity, and cytokine levels were determined Results: Breast cancer surgery induces a pro-inflammatory response and leucocytosis Immunosuppression is indicated by decreased HLA-DR expression. decreased NKCA. and a Th2 response A delayed Th1 response was also found 5 days after surgery As no cortisol level change was observed, this hormone can be excluded as the mediator of surgery-related immunomodulation in breast cancer Conclusion: Although breast cancer surgery is classified as minor surgery the surgical procedure produces substantial immunomodulation J Surg Oncol 2010,102 640-648 (C) 2010 Wiley-Liss, Inc

引用

页码：640 / 648

页数：9

共 40 条

[1]

BALLOU SP, 1992, ADV INTERNAL MED, V37, P313

[2] NATURAL IMMUNITY IN BREAST-CANCER PATIENTS DURING NEOADJUVANT CHEMOTHERAPY AND AFTER SURGERY [J].

BEITSCH, P ;

LOTZOVA, E ;

HORTOBAGYI, G ;

POLLOCK, R .

SURGICAL ONCOLOGY-OXFORD, 1994, 3 (04) :211-219

[3]

Ben-Eliyahu S, 1999, INT J CANCER, V80, P880

[4]

Ben-Eliyahu S, 2003, BRAIN BEHAV IMMUN, V17, pS27

[5]

Ben-Eliyahu S, 2002, LANCET ONCOL, V3, P578

[6] STRESS INCREASES METASTATIC SPREAD OF A MAMMARY-TUMOR IN RATS - EVIDENCE FOR MEDIATION BY THE IMMUNE-SYSTEM [J].

BENELIYAHU, S ;

YIRMIYA, R ;

LIEBESKIND, JC ;

TAYLOR, AN ;

GALE, RP .

BRAIN BEHAVIOR AND IMMUNITY, 1991, 5 (02) :193-205

[7] Normal T lymphocyte and monocyte function after minimally invasive surgery [J].

Brune, IB ;

Wilke, W ;

Hensler, T ;

Feussner, H ;

Holzmann, B ;

Siewert, JR .

SURGICAL ENDOSCOPY-ULTRASOUND AND INTERVENTIONAL TECHNIQUES, 1998, 12 (08) :1020-1024

[8]

FAWZY FI, 1993, ARCH GEN PSYCHIAT, V50, P681

[9]

FISHMAN P, 1993, NAT IMMUN, V12, P35

[10]

Goldfarb Y, 2006, Breast Dis, V26, P99

← 1 2 3 4 →