Limonoids with anti-inflammatory activity: A review

被引：19

作者：

Hilmayanti, Erina ^{[1
,3
]}

Nurlelasari ^{[1
]}

Supratman, Unang ^{[1
,2
]}

Kabayama, Kazuya ^{[3
]}

Shimoyama, Atsushi ^{[3
]}

Fukase, Koichi ^{[3
]}

机构：

[1] Univ Padjadjaran, Fac Math & Nat Sci, Dept Chem, Sumedang 45363, West Java, Indonesia

[2] Univ Padjadjaran, Cent Lab, Sumedang 45363, West Java, Indonesia

[3] Osaka Univ, Grad Sch Sci, Dept Chem, 1-1 Machikaneyama Cho, Toyonaka, Osaka 5600043, Japan

来源：

PHYTOCHEMISTRY | 2022年 / 204卷

关键词：

Anti-inflammatory activity; Limonoid; Meliaceae; Rutaceae; Content list; NITRIC-OXIDE PRODUCTION; MEXICANOLIDE-TYPE LIMONOIDS; MELANOGENESIS-INHIBITORY ACTIVITIES; CARAPA-GUIANENSIS ANDIROBA; C-SECO LIMONOIDS; NF-KAPPA-B; AZADIRACHTA-INDICA; MELIA-AZEDARACH; TRICHILIA-CONNAROIDES; CITRUS LIMONOIDS;

D O I：

10.1016/j.phytochem.2022.113469

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The natural limonoids distributed mainly in the Meliaceae and Rutaceae plants are known for their unique and complex structure with high degree oxidation and cyclic rearrangement. However, these compounds exhibit a broad range of biological activities such as insecticidal, antibacterial, antifungal, antimalarial, antioxidant, anticancer, antiviral, and anti-inflammatory. There is still limited report about the biological activity of the anti-inflammatory effect of limonoids isolated from plants. Therefore, this study aimed to examine the effect of intact, deformed and rearranged limonoids as anti-inflammatory agents. The majority of anti-inflammatory in-vestigations were evaluated by in vitro and in vivo assays of the isolated pure compounds and their derivatives. For the in vitro study, intact and C-ring seco limonoids showed a potent inhibitory effect against NO production. The in vivo analysis of Intact, C-seco, and AD-seco limonoids showed a potent effect based on the inhibition of pro-inflammatory cytokines expression, indicating their potency as anti-inflammatory agents.

引用

页数：31

共 172 条

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