Salmonella, E. coli, and Citrobacter Type III Secretion System Effector Proteins that Alter Host Innate Immunity

被引：3

作者：

El Qaidi, Samir ^{[1
]}

Wu, Miaomiao ^{[1
]}

Zhu, Congrui ^{[1
]}

Hardwidge, Philip R. ^{[1
]}

机构：

[1] Kansas State Univ, Coll Vet Med, Manhattan, KS 66506 USA

来源：

PROTEIN REVIEWS - PURINERGIC RECEPTORS, VOL 20 | 2019年 / 1111卷

基金：

美国国家卫生研究院;

关键词：

Bacterial pathogenesis; Effector; Innate immunity; Type III secretion; Virulence; NF-KAPPA-B; ENTEROPATHOGENIC ESCHERICHIA-COLI; PATHOGENICITY ISLAND; BACTERIAL EFFECTOR; GLYCOSYLTRANSFERASE ACTIVITY; PHOSPHOTHREONINE LYASE; SUBSTRATE RECOGNITION; TYROSINE-PHOSPHATASE; TYPHIMURIUM; VIRULENCE;

D O I：

10.1007/5584_2018_289

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacteria deliver virulence proteins termed 'effectors' to counteract host innate immunity. Protein-protein interactions within the host cell ultimately subvert the generation of an inflammatory response to the infecting pathogen. Here we briefly describe a subset of T3SS effectors produced by enterohemorrhagic Escherichia coli (EHEC), enteropathogenic E. coli (EPEC), Citrobacter rodentium, and Salmonella enterica that inhibit innate immune pathways. These effectors are interesting for structural and mechanistic reasons, as well as for their potential utility in being engineered to treat human autoimmune disorders associated with perturbations in NF-kappa B signaling.

引用

页码：205 / 218

页数：14

共 109 条

[41] A secreted protein tyrosine phosphatase with modular effector domains in the bacterial pathogen Salmonella typhimurium [J].

Kaniga, K ;

Uralil, J ;

Bliska, JB ;

Galan, JE .

MOLECULAR MICROBIOLOGY, 1996, 21 (03) :633-641

[42] IDENTIFICATION OF 2 TARGETS OF THE TYPE-III PROTEIN SECRETION SYSTEM ENCODED BY THE INV AND SPA LOCI OF SALMONELLA-TYPHIMURIUM THAT HAVE HOMOLOGY TO THE SHIGELLA IPAD AND IPAA PROTEINS [J].

KANIGA, K ;

TROLLINGER, D ;

GALAN, JE .

JOURNAL OF BACTERIOLOGY, 1995, 177 (24) :7078-7085

[43] A Salmonella Virulence Factor Activates the NOD1/NOD2 Signaling Pathway [J].

Keestra, A. Marijke ;

Winter, Maria G. ;

Klein-Douwel, Daisy ;

Xavier, Mariana N. ;

Winter, Sebastian E. ;

Kim, Anita ;

Tsolis, Renee M. ;

Baeumler, Andreas J. .

MBIO, 2011, 2 (06)

[44] Essential role of the type III secretion system effector NleB in colonization of mice by Citrobacter rodentium [J].

Kelly, M ;

Hart, E ;

Mundy, R ;

Marchès, O ;

Wiles, S ;

Badea, L ;

Luck, S ;

Tauschek, M ;

Frankel, G ;

Robins-Browne, RM ;

Hartland, EL .

INFECTION AND IMMUNITY, 2006, 74 (04) :2328-2337

[45] Enteropathogenic E-coli (EPEC) transfers its receptor for intimate adherence into mammalian cells [J].

Kenny, B ;

DeVinney, R ;

Stein, M ;

Reinscheid, DJ ;

Frey, EA ;

Finlay, BB .

CELL, 1997, 91 (04) :511-520

[46] Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin Ligase [J].

Keszei, Alexander F. A. ;

Tang, Xiaojing ;

McCormick, Craig ;

Zeqiraj, Elton ;

Rohde, John R. ;

Tyers, Mike ;

Sicheri, Frank .

MOLECULAR AND CELLULAR BIOLOGY, 2014, 34 (03) :362-373

[47] The bacterial virulence factor NleA inhibits cellular protein secretion by disrupting mammalian COPII function [J].

Kim, Jinoh ;

Thanabalasuriar, Ajitha ;

Chaworth-Musters, Tessa ;

Fromme, J. Chris ;

Frey, Elizabeth A. ;

Lario, Paula I. ;

Metalnikov, Pavel ;

Rizg, Keyrillos ;

Thomas, Nikhil A. ;

Lee, Sau Fung ;

Hartland, Elizabeth L. ;

Hardwidge, Philip R. ;

Pawson, Tony ;

Strynadka, Natalie C. ;

Finlay, B. Brett ;

Schekman, Randy ;

Gruenheid, Samantha .

CELL HOST & MICROBE, 2007, 2 (03) :160-171

[48] Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systems [J].

Knodler, LA ;

Celli, J ;

Hardt, WD ;

Vallance, BA ;

Yip, C ;

Finlay, BB .

MOLECULAR MICROBIOLOGY, 2002, 43 (05) :1089-1103

[49] A Sorting Platform Determines the Order of Protein Secretion in Bacterial Type III Systems [J].

Lara-Tejero, Maria ;

Kato, Junya ;

Wagner, Samuel ;

Liu, Xiaoyun ;

Galan, Jorge E. .

SCIENCE, 2011, 331 (6021) :1188-1191

[50] Salmonella secreted factor L deubiquitinase of Salmonella typhimurium inhibits NF-κB, suppresses IκBα ubiquitination and modulates innate immune responses [J].

Le Negrate, Gaelle ;

Faustin, Benjamin ;

Welsh, Kate ;

Loeffler, Markus ;

Krajewska, Maryla ;

Hasegawa, Patty ;

Mukherjee, Sohini ;

Orth, Kim ;

Krajewski, Stan ;

Godzik, Adam ;

Guiney, Donald G. ;

Reed, John C. .

JOURNAL OF IMMUNOLOGY, 2008, 180 (07) :5045-5056

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