Salmonella, E. coli, and Citrobacter Type III Secretion System Effector Proteins that Alter Host Innate Immunity

被引：3
作者：
El Qaidi, Samir [1 ]
Wu, Miaomiao [1 ]
Zhu, Congrui [1 ]
Hardwidge, Philip R. [1 ]
机构：
[1] Kansas State Univ, Coll Vet Med, Manhattan, KS 66506 USA
来源：
PROTEIN REVIEWS - PURINERGIC RECEPTORS, VOL 20 | 2019年 / 1111卷
基金：
美国国家卫生研究院;
关键词：
Bacterial pathogenesis; Effector; Innate immunity; Type III secretion; Virulence; NF-KAPPA-B; ENTEROPATHOGENIC ESCHERICHIA-COLI; PATHOGENICITY ISLAND; BACTERIAL EFFECTOR; GLYCOSYLTRANSFERASE ACTIVITY; PHOSPHOTHREONINE LYASE; SUBSTRATE RECOGNITION; TYROSINE-PHOSPHATASE; TYPHIMURIUM; VIRULENCE;
D O I：
10.1007/5584_2018_289
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bacteria deliver virulence proteins termed 'effectors' to counteract host innate immunity. Protein-protein interactions within the host cell ultimately subvert the generation of an inflammatory response to the infecting pathogen. Here we briefly describe a subset of T3SS effectors produced by enterohemorrhagic Escherichia coli (EHEC), enteropathogenic E. coli (EPEC), Citrobacter rodentium, and Salmonella enterica that inhibit innate immune pathways. These effectors are interesting for structural and mechanistic reasons, as well as for their potential utility in being engineered to treat human autoimmune disorders associated with perturbations in NF-kappa B signaling.
引用
收藏
页码：205 / 218
页数：14
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