Role of macrophage scavenger receptors in atherosclerosis
被引:225
作者:
Kzhyshkowska, Julia
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机构:
Univ Heidelberg, Med Fac Mannheim, Dept Dermatol, D-68167 Mannheim, Germany
Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow, RussiaUniv Heidelberg, Med Fac Mannheim, Dept Dermatol, D-68167 Mannheim, Germany
Kzhyshkowska, Julia
[1
,2
]
Neyen, Claudine
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机构:
Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
Ecole Polytech Fed Lausanne, Global Hlth Inst, Lausanne, SwitzerlandUniv Heidelberg, Med Fac Mannheim, Dept Dermatol, D-68167 Mannheim, Germany
Neyen, Claudine
[3
,4
]
Gordon, Siamon
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h-index: 0
机构:
Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, EnglandUniv Heidelberg, Med Fac Mannheim, Dept Dermatol, D-68167 Mannheim, Germany
Gordon, Siamon
[3
]
机构:
[1] Univ Heidelberg, Med Fac Mannheim, Dept Dermatol, D-68167 Mannheim, Germany
[2] Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow, Russia
[3] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
[4] Ecole Polytech Fed Lausanne, Global Hlth Inst, Lausanne, Switzerland
Accumulating evidence indicates that atherosclerosis is a chronic inflammatory disease. The key innate immune cells that are involved in the pathogenesis of atherosclerosis are circulating monocytes and plaque macrophages. Complex interplay between immune and metabolic processes results in pathological activity of these cells. The best understood pathological process mediated by macrophages is their inability to process modified lipoproteins properly resulting in the formation of foamy cells, which are a dangerous component of atherosclerotic plaques. Key molecules involved in the recognition and processing of modified lipoproteins are scavenger receptors (SR). This is a large family of surface expressed structurally heterogeneous receptors with a broad spectrum of endogenous and exogenous ligands. The common functional feature of SR is internalisation of extracellular components and targeting them for lysosomal degradation. However, these relatively simple functions can have complex consequences, since they are linked to diverse specific signalling pathways and to other membrane transport pathways. Moreover, scavenger receptors can co-operate with other types of receptors increasing the variability of the macrophage response to multiple extracellular ligands. At least some SRs respond to modified lipoproteins by amplification of inflammation and accumulation of macrophages in the plaque, while some SRs may support tolerogenic reactions. Outcome of different SR activities will be the decision of monocytes and macrophage to guard homeostatic balance, support atherosclerosis progression and plaque instability by inflammatory reactions, or support rapid fibrotic processes in the plaque that stabilise it. Despite the accumulating knowledge about the molecular mechanisms of scavenger receptor action, their role in the progression of atherosclerosis remains controversial. The activities of scavenger receptors that can contribute to each of these processes are a subject of current review. (C) 2012 Elsevier GmbH. All rights reserved.
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Hop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Univ Paris 06, Paris, France
Hop Pitie, Inst CardioMetab & Nutr, F-75651 Paris 13, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Bellanger, Natacha
;
Orsoni, Alexina
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机构:
Hop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Univ Paris 06, Paris, France
Hop Pitie, Inst CardioMetab & Nutr, F-75651 Paris 13, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Orsoni, Alexina
;
Julia, Zelie
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h-index: 0
机构:
Hop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Univ Paris 06, Paris, France
Hop Pitie, Inst CardioMetab & Nutr, F-75651 Paris 13, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Julia, Zelie
;
Fournier, Natalie
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h-index: 0
机构:
Univ Paris Sud, Unite Federat Rech Pharm, Chatenay Malabry, France
Hop Europeen Georges Pompidou, AP HP, Serv Biochim, Paris, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Fournier, Natalie
;
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Frisdal, Eric
;
Duchene, Emilie
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h-index: 0
机构:
Hop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Hop Pitie, AP HP, Dept Endocrinol, F-75651 Paris 13, France
Univ Paris 06, Paris, France
Hop Pitie, Inst CardioMetab & Nutr, F-75651 Paris 13, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Duchene, Emilie
;
Bruckert, Eric
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h-index: 0
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Hop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Hop Pitie, AP HP, Dept Endocrinol, F-75651 Paris 13, France
Hop Pitie, Inst CardioMetab & Nutr, F-75651 Paris 13, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Bruckert, Eric
;
Carrie, Alain
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h-index: 0
机构:
Hop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Univ Paris 06, Paris, France
Hop Pitie, Inst CardioMetab & Nutr, F-75651 Paris 13, France
Hop La Pitie Salpetriere, AP HP, Unit Mol & Oncol Endocrinol, Paris, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Carrie, Alain
;
Bonnefont-Rousselot, Dominique
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机构:
Hop Pitie, AP HP, Dept Metab Biochem, F-75651 Paris 13, France
Paris Descartes Univ, Fac Pharm, Dept Expt Metab & Clin Biol, Paris, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Bonnefont-Rousselot, Dominique
;
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Pirault, John
;
Saint-Charles, Flora
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h-index: 0
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Hop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Univ Paris 06, Paris, France
Hop Pitie, Inst CardioMetab & Nutr, F-75651 Paris 13, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Saint-Charles, Flora
;
Chapman, M. John
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Hop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Univ Paris 06, Paris, France
Hop Pitie, Inst CardioMetab & Nutr, F-75651 Paris 13, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Chapman, M. John
;
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Lesnik, Philippe
;
Le Goff, Wilfried
论文数: 0引用数: 0
h-index: 0
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Hop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Univ Paris 06, Paris, France
Hop Pitie, Inst CardioMetab & Nutr, F-75651 Paris 13, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
机构:
Univ Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Hop La Pitie Salpetriere, Dept Pathol, AP HP, Paris, FranceUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Brocheriou, Isabelle
;
Maouche, Seraya
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h-index: 0
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Univ Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, FranceUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Maouche, Seraya
;
Durand, Herve
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Univ Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, FranceUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Durand, Herve
;
Braunersreuther, Vincent
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Univ Hosp, Div Cardiol, Fdn Med Res, Geneva, SwitzerlandUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Braunersreuther, Vincent
;
Le Naour, Gilles
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Hop La Pitie Salpetriere, Dept Pathol, AP HP, Paris, FranceUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Le Naour, Gilles
;
Gratchev, Alexei
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机构:
Univ Heidelberg, Univ Med Ctr Mannheim, D-6900 Heidelberg, Germany
Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow, RussiaUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Gratchev, Alexei
;
Koskas, Fabien
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Univ Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Hop La Pitie Salpetriere, Dept Vasc Surg, AP HP, Paris, FranceUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Koskas, Fabien
;
Mach, Francois
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Univ Hosp, Div Cardiol, Fdn Med Res, Geneva, SwitzerlandUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Mach, Francois
;
Kzhyshkowska, Julia
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h-index: 0
机构:
Univ Heidelberg, Univ Med Ctr Mannheim, D-6900 Heidelberg, Germany
Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow, RussiaUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Kzhyshkowska, Julia
;
Ninio, Ewa
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Univ Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, FranceUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
机构:
Hop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Univ Paris 06, Paris, France
Hop Pitie, Inst CardioMetab & Nutr, F-75651 Paris 13, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Bellanger, Natacha
;
Orsoni, Alexina
论文数: 0引用数: 0
h-index: 0
机构:
Hop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Univ Paris 06, Paris, France
Hop Pitie, Inst CardioMetab & Nutr, F-75651 Paris 13, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Orsoni, Alexina
;
Julia, Zelie
论文数: 0引用数: 0
h-index: 0
机构:
Hop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Univ Paris 06, Paris, France
Hop Pitie, Inst CardioMetab & Nutr, F-75651 Paris 13, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Julia, Zelie
;
Fournier, Natalie
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h-index: 0
机构:
Univ Paris Sud, Unite Federat Rech Pharm, Chatenay Malabry, France
Hop Europeen Georges Pompidou, AP HP, Serv Biochim, Paris, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Fournier, Natalie
;
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Frisdal, Eric
;
Duchene, Emilie
论文数: 0引用数: 0
h-index: 0
机构:
Hop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Hop Pitie, AP HP, Dept Endocrinol, F-75651 Paris 13, France
Univ Paris 06, Paris, France
Hop Pitie, Inst CardioMetab & Nutr, F-75651 Paris 13, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Duchene, Emilie
;
Bruckert, Eric
论文数: 0引用数: 0
h-index: 0
机构:
Hop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Hop Pitie, AP HP, Dept Endocrinol, F-75651 Paris 13, France
Hop Pitie, Inst CardioMetab & Nutr, F-75651 Paris 13, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Bruckert, Eric
;
Carrie, Alain
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h-index: 0
机构:
Hop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Univ Paris 06, Paris, France
Hop Pitie, Inst CardioMetab & Nutr, F-75651 Paris 13, France
Hop La Pitie Salpetriere, AP HP, Unit Mol & Oncol Endocrinol, Paris, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Carrie, Alain
;
Bonnefont-Rousselot, Dominique
论文数: 0引用数: 0
h-index: 0
机构:
Hop Pitie, AP HP, Dept Metab Biochem, F-75651 Paris 13, France
Paris Descartes Univ, Fac Pharm, Dept Expt Metab & Clin Biol, Paris, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Bonnefont-Rousselot, Dominique
;
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Pirault, John
;
Saint-Charles, Flora
论文数: 0引用数: 0
h-index: 0
机构:
Hop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Univ Paris 06, Paris, France
Hop Pitie, Inst CardioMetab & Nutr, F-75651 Paris 13, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Saint-Charles, Flora
;
Chapman, M. John
论文数: 0引用数: 0
h-index: 0
机构:
Hop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Univ Paris 06, Paris, France
Hop Pitie, Inst CardioMetab & Nutr, F-75651 Paris 13, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Chapman, M. John
;
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Lesnik, Philippe
;
Le Goff, Wilfried
论文数: 0引用数: 0
h-index: 0
机构:
Hop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
Univ Paris 06, Paris, France
Hop Pitie, Inst CardioMetab & Nutr, F-75651 Paris 13, FranceHop Pitie, INSERM, UMRS 939, F-75651 Paris 13, France
机构:
Univ Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Hop La Pitie Salpetriere, Dept Pathol, AP HP, Paris, FranceUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Brocheriou, Isabelle
;
Maouche, Seraya
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, FranceUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Maouche, Seraya
;
Durand, Herve
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, FranceUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Durand, Herve
;
Braunersreuther, Vincent
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp, Div Cardiol, Fdn Med Res, Geneva, SwitzerlandUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Braunersreuther, Vincent
;
Le Naour, Gilles
论文数: 0引用数: 0
h-index: 0
机构:
Hop La Pitie Salpetriere, Dept Pathol, AP HP, Paris, FranceUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Le Naour, Gilles
;
Gratchev, Alexei
论文数: 0引用数: 0
h-index: 0
机构:
Univ Heidelberg, Univ Med Ctr Mannheim, D-6900 Heidelberg, Germany
Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow, RussiaUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Gratchev, Alexei
;
Koskas, Fabien
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Hop La Pitie Salpetriere, Dept Vasc Surg, AP HP, Paris, FranceUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Koskas, Fabien
;
Mach, Francois
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp, Div Cardiol, Fdn Med Res, Geneva, SwitzerlandUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Mach, Francois
;
Kzhyshkowska, Julia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Heidelberg, Univ Med Ctr Mannheim, D-6900 Heidelberg, Germany
Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow, RussiaUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France
Kzhyshkowska, Julia
;
Ninio, Ewa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, FranceUniv Paris 06, INSERM, UMRS937, Fac Med Pierre & Marie Curie, F-75634 Paris, France