The functions of estrogen receptor beta in the female brain: A systematic review

被引：41

作者：

Vargas, Kris G. ^{[1
]}

Milic, Jelena ^{[1
]}

Zaciragic, Asija ^{[1
]}

Wen, Ke-xin ^{[1
]}

Jaspers, Loes ^{[1
]}

Nano, Jana ^{[1
]}

Dhana, Klodian ^{[1
]}

Bramer, Wichor M. ^{[2
]}

Kraja, Bledar ^{[1
,3
,4
]}

van Beeck, Ed ^{[5
]}

Ikram, M. Arfan ^{[1
,6
,7
]}

Muka, Taulant ^{[1
]}

Franco, Oscar H. ^{[1
]}

机构：

[1] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[2] Erasmus MC, Med Lib, Rotterdam, Netherlands

[3] Univ Med, Fac Med, Dept Biomed Sci, Tirana, Albania

[4] Univ Hosp Ctr Mother Teresa, Univ Clin Gastrohepatol, Tirana, Albania

[5] Erasmus Univ, Med Ctr, Dept Publ Hlth, Rotterdam, Netherlands

[6] Erasmus Univ, Med Ctr, Dept Neurol, Rotterdam, Netherlands

[7] Erasmus Univ, Med Ctr, Dept Radiol, Rotterdam, Netherlands

来源：

MATURITAS | 2016年 / 93卷

关键词：

Estrogen receptor beta; Neurological disorders; Psychiatry; Brain; Menopause; Systematic review; ELEMENT-BINDING PROTEIN; SYNAPTIC PLASTICITY; CELL-PROLIFERATION; RECOGNITION MEMORY; DENTATE GYRUS; IN-VIVO; OVARIECTOMIZED RATS; SIGNALING PATHWAYS; HORMONE NEURONS; ESTRADIOL ACTS;

D O I：

10.1016/j.maturitas.2016.05.014

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Females have unique and additional risk factors for neurological disorders. Among classical estrogen receptors, estrogen receptor beta (ER beta) has been suggested as a therapeutic target. However, little is known about the role of ER beta in the female brain. Six electronic databases were searched for articles evaluating the role of ER beta in the female brain and the influence of age and menopause on ER beta function. After screening 3186 titles and abstracts, 49 articles were included in the review, all of which were animal studies. Of these, 19 focused on cellular signaling, 7 on neuroendocrine pathways, 8 on neurological disorders, 4 on neuroprotection and 19 on psychological and psychiatric outcomes (6 studies evaluated two or more outcomes). Our findings showed that ER beta phosphorylated and activated intracellular second messenger proteins and regulated protein expression of genes involved in neurological functions. It also promoted neurogenesis, modulated the neuroendocrine regulation of stress response, conferred neuroprotection against ischemia and inflammation, and reduced anxiety- and depression-like behaviors. Targeting ER beta may constitute a novel treatment for menopausal symptoms, including anxiety, depression, and neurological diseases. However, to establish potential therapeutic and preventive strategies targeting ER beta, future studies should be conducted in humans to further our understanding of the importance of ER beta in women's mental and cognitive health. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：41 / 57

页数：17

共 77 条

[1] Critical in vivo roles for classical estrogen receptors in rapid estrogen actions on intracellular signaling in mouse brain [J].