Iridium-catalyzed α-Alkylation of Acetonitrile with Primary and Secondary Alcohols

被引：50

作者：

Sawaguchi, Takuya ^{[1
]}

Obora, Yasushi ^{[1
]}

机构：

[1] Kansai Univ, Fac Chem Mat & Bioengn, Dept Chem & Mat Engn, Osaka 5648680, Japan

来源：

CHEMISTRY LETTERS | 2011年 / 40卷 / 09期

关键词：

ONE-POT SYNTHESIS; OXIDATIVE CONVERSION; HIGHLY EFFICIENT; BETA-ALKYLATION; PRIMARY AMINES; TETRABUTYLAMMONIUM PEROXYDISULFATE; BORROWING HYDROGEN; ORGANIC-SYNTHESIS; COUPLING REACTION; CARBOXYLIC-ACIDS;

D O I：

10.1246/cl.2011.1055

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Acetonitrile is successfully alkylated with primary and secondary alcohols in the presence of t-BuOK using [Ir(OH)(cod)](2) as a catalyst. This method provides a very clean and atom-economical convenient direct route to substituted nitriles, which are very important raw materials in organic and industrial chemistry.

引用

页码：1055 / 1057

页数：3

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