Iridium-catalyzed α-Alkylation of Acetonitrile with Primary and Secondary Alcohols

被引：50
作者：
Sawaguchi, Takuya [1 ]
Obora, Yasushi [1 ]
机构：
[1] Kansai Univ, Fac Chem Mat & Bioengn, Dept Chem & Mat Engn, Osaka 5648680, Japan
来源：
CHEMISTRY LETTERS | 2011年 / 40卷 / 09期
关键词：
ONE-POT SYNTHESIS; OXIDATIVE CONVERSION; HIGHLY EFFICIENT; BETA-ALKYLATION; PRIMARY AMINES; TETRABUTYLAMMONIUM PEROXYDISULFATE; BORROWING HYDROGEN; ORGANIC-SYNTHESIS; COUPLING REACTION; CARBOXYLIC-ACIDS;
D O I：
10.1246/cl.2011.1055
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Acetonitrile is successfully alkylated with primary and secondary alcohols in the presence of t-BuOK using [Ir(OH)(cod)](2) as a catalyst. This method provides a very clean and atom-economical convenient direct route to substituted nitriles, which are very important raw materials in organic and industrial chemistry.
引用
收藏
页码：1055 / 1057
页数：3
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