Role of Na+-Ca2+ exchanger in myocardial ischemia/reperfusion injury:: evaluation using a heterozygous Na+-Ca2+ exchanger knockout mouse model

被引：36
|
作者：
Ohtsuka, M
Takano, H
Suzuki, M
Zou, Y
Akazawa, H
Tamagawa, M
Wakimoto, K
Nakaya, H
Komuro, I
机构：
[1] Chiba Univ, Grad Sch Med, Dept Cardiovasc Sci & Med, Chuo Ku, Chiba 2608670, Japan
[2] Chiba Univ, Grad Sch Med, Dept Pharmacol, Chuo Ku, Chiba 2608670, Japan
[3] Tanabe Seiyaku Co Ltd, Discovery Res Lab, Yodogawa Ku, Osaka 5328505, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 314卷 / 03期
关键词：
sodium-calcium exchanger; knockout mouse; heart; ischemia/reperfusion injury;
D O I：
10.1016/j.bbrc.2003.12.165
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We used Na+-Ca2+ exchanger (NCX) knockout mice to evaluate the effects of NCX in cardiac function and the infarct size after ischemia/reperfusion injury. The contractile function in NCX KO mice hearts was significantly better than that in wild type (WT) mice hearts after ischemia/reperfusion and the infarct size was significantly small in NCX KO mice hearts compared with that in WT mice hearts. NCX is critically involved in the development of ischemia/reperfusion-induced myocardial injury and therefore the inhibition of NCX function may contribute to cardioprotection against ischemia/reperfusion injury. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码：849 / 853
页数：5
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