Increased 5-year risk of stroke, atrial fibrillation, acute coronary syndrome, and heart failure in out- of-hospital cardiac arrest survivors compared with population controls: A nationwide registry-based study

被引：7

作者：

Byrne, Christina ^{[1
]}

Pareek, Manan ^{[2
]}

Krogager, Maria Lukacs ^{[3
]}

Ringgren, Kristian B. ^{[3
]}

Wissenberg, Mads ^{[4
]}

Folke, Fredrik ^{[4
,5
]}

Lippert, Freddy ^{[5
]}

Gislason, Gunnar ^{[4
]}

Kober, Lars ^{[1
]}

Sogaard, Peter ^{[3
]}

Lip, Gregory Y. H. ^{[6
,7
,8
]}

Torp-Pedersen, Christian ^{[2
]}

Kragholm, Kristian ^{[3
]}

机构：

[1] Copenhagen Univ Hosp, Dept Cardiol, Rigshosp, Copenhagen, Denmark

[2] North Zealand Hosp, Dept Cardiol, Hillerod, Denmark

[3] Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark

[4] Herlev Gentofte Univ Hosp, Dept Cardiol, Herlev, Denmark

[5] Univ Copenhagen, Copenhagen Emergency Med Serv, Copenhagen, Denmark

[6] Univ Liverpool, Liverpool Ctr Cardiovasc Sci, Liverpool, Merseyside, England

[7] Liverpool Heart & Chest Hosp, Liverpool, Merseyside, England

[8] Aalborg Univ, Dept Clin Med, Aalborg, Denmark

来源：

RESUSCITATION | 2021年 / 169卷

关键词：

Out-of-hospital cardiac arrest survivors; Long-term risk; Stroke; Atrial fibrillation and atrial flutter; Acute coronary syndrome; Heart failure; RESUSCITATION-COUNCIL GUIDELINES; TERM CLINICAL-OUTCOMES; SECTION; 4; MANAGEMENT; DISCHARGE;

D O I：

10.1016/j.resuscitation.2021.10.024

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Aim: Long-term risks of stroke, atrial fibrillation, or flutter (AF), acute coronary syndrome (ACS), and heart failure (HF) among survivors of out-of hospital cardiac arrest (OHCA) are unknown. We aimed to examine 5-year risks of these outcomes among 30-day survivors of OHCA. Methods: Thirty-day survivors of OHCA without a prior (or within 30 days after cardiac arrest) history of stroke, AF, ACS, or HF and population controls without a prior history of these conditions were identified using Danish nationwide registries. Five-year risks of stroke, AF, ACS, and HF standardized to the distributions of age, sex, and comorbidities among OHCA survivors and controls were obtained using multivariable regression. Results: Of 4,362 30-day OHCA-survivors, 1,051 were stroke-, AF-, ACS-, and HF-nai spacing diaeresis ve and matched with controls using age, sex, and time of OHCA event. Absolute five-year risks for OHCA survivors vs. controls were for stroke: 6.3% [95% confidence interval (CI) 4.1-8.5] vs. 2.0% [1.6- 2.5], AF: 7.9% [5.7-10.2] vs. 2.6% [2.1-3.1], ACS: 5.0% [3.2-6.8] vs. 1.5% [1.1-1.9], and HF: 12.7% [10.1-15.4] vs. 1.2% [0.9-1.6], respectively. Corresponding relative risks were 3.18 [95% CI 1.76-4.61] for stroke, 3.03 [1.93-4.14] for AF, 3.23 [1.69-4.77] for ACS, and 10.40 [6.57-14.13] for HF. Conclusion: When compared with population controls, OHCA survivors had significantly increased five-year risks of incident stroke, AF, ACS, and HF.

引用

页码：53 / 59

页数：7