Bradykinin receptors in the zebrafish (Danio rerio)

被引：1

作者：

Bromée, T

Conlon, JM

Larhammar, D

机构：

[1] Uppsala Univ, Pharmacol Unit, Dept Neurosci, SE-75124 Uppsala, Sweden

[2] United Arab Emirates Univ, Fac Med & Hlth Sci, Dept Biochem, Al Ain 17666, U Arab Emirates

来源：

TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY | 2005年 / 1040卷

关键词：

bradykinin receptor; inositol phosphates (IP); alanine; D-isomer;

D O I：

10.1196/annals.1327.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ligand interactions of a zebrafish bradykinin (BK) receptor expressed in vitro were characterized by measuring inositol phosphate accumulation. The ligands were analogues of zebrafish BK. Substitutions of Arg1, Gly4, Ser6, Pro7, Leu8, and Arg9 caused greatly reduced potency and maximum response. The Pro3 to Ala analogue had higher potency, but lower maximum response. These and other differences show that the zebrafish BK receptor has a ligand-interaction profile that is distinct from mammalian B1 and B2 receptors and from the previously characterized BK receptor in trout stomach. The results increase our understanding of the evolution of BK receptors and their ligands.

引用

页码：246 / 248

页数：3

共 6 条

[1] Pharmacological characterization of ligand-receptor interactions at the zebrafish bradykinin receptor [J].