Major depressive disorder;
Insula;
Functional connectivity;
Fronto-limbic circuit;
Hate circuit;
SUPERIOR TEMPORAL GYRUS;
FUNCTIONAL CONNECTIVITY;
REGIONAL HOMOGENEITY;
DEFAULT-MODE;
HIGH-RISK;
STATE;
1ST-EPISODE;
MRI;
ADOLESCENTS;
FMRI;
D O I:
10.1016/j.jad.2015.03.028
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
Background: The insula has extensive links to the fronto-limbic circuit and associated regions, which is involved in the neurobiology of major depressive disorder (MDD). However, few studies are designed to examine the insular connectivity in MDD. This study was performed to examine the insular connectivity in drug-naive MDD directly by using the insular cortices as seeds. Methods: Functional magnetic resonance imaging data were obtained from 44 drug naive MOD patients and 44 healthy controls at rest. The functional connectivity (PC) method was used to analyze the images. Results: Significantly decreased FCs were found between the right insula and the left middle frontal gyrus (MFG, orbital part), left superior temporal gyros (STG), right putamen, and right middle occipital gyrus (MOG), and between the left insula and the left superior temporal pole and right MOG in the patients compared with the controls. There were significantly negative correlations between the z values of the left insula-left superior temporal pole connectivity and the current episode duration (r= -0.332, p=0.028), between the z values of the right insula-left STG connectivity and the episode number (r= -0.343, p =0.023), and between the z values of the right insula-left MFG (orbital part) connectivity and the Automatic Thoughts Questionnaire scores (r= -0.359, p=0.017) in the patients. Conclusions: The findings reveal that depressed patients have decreased insular connectivity with the fronto-limbic circuit, hate circuit, and visual regions, and suggest that the insula may act as an integration center of emotional processing which is disrupted in the depressed patients. (C) 2015 Elsevier B.V. All rights reserved
机构:
Cent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Chen, Jin-dong
Liu, Feng
论文数: 0引用数: 0
h-index: 0
机构:
Univ Elect Sci & Technol China, Minist Educ, Sch Life Sci & Technol, Key Lab Neuroinformat, Chengdu 610054, Sichuan, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Liu, Feng
Xun, Guang-lei
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Mental Hlth Ctr, Jinan 250014, Shandong, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Xun, Guang-lei
Chen, Hua-fu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Elect Sci & Technol China, Minist Educ, Sch Life Sci & Technol, Key Lab Neuroinformat, Chengdu 610054, Sichuan, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Chen, Hua-fu
Hu, Mao-rong
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Hu, Mao-rong
Guo, Xiao-feng
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Guo, Xiao-feng
Xiao, Chang-qing
论文数: 0引用数: 0
h-index: 0
机构:
Guangxi Med Univ, Affiliated Hosp 1, Mental Hlth Ctr, Nanning 530021, Guangxi, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Xiao, Chang-qing
Wooderson, Sarah C.
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Inst Psychiat, Dept Psychol Med, London WC2R 2LS, EnglandCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Wooderson, Sarah C.
Guo, Wen-bin
论文数: 0引用数: 0
h-index: 0
机构:
Guangxi Med Univ, Affiliated Hosp 1, Mental Hlth Ctr, Nanning 530021, Guangxi, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Guo, Wen-bin
Zhao, Jing-ping
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Hangzhou Seventh People Hosp, Hangzhou 310001, Zhejiang, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
机构:
NYU, Sch Med, Dept Child & Adolescent Psychiat, New York Child Study Ctr, New York, NY USAUniv Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA
机构:
NYU, Sch Med, Dept Child & Adolescent Psychiat, New York Child Study Ctr, New York, NY USA
Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USAUniv Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA
Gabbay, Vilma
Hulvershorn, Leslie
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Child & Adolescent Psychiat, New York Child Study Ctr, New York, NY USAUniv Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA
机构:
Univ Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA
Vet Adm Med Ctr, Minneapolis, MN 55417 USAUniv Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA
Lim, Kelvin O.
Castellanos, F. Xavier
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Child & Adolescent Psychiat, New York Child Study Ctr, New York, NY USA
Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USAUniv Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA
Castellanos, F. Xavier
Milham, Michael P.
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Child & Adolescent Psychiat, New York Child Study Ctr, New York, NY USAUniv Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA
机构:
Cent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Chen, Jin-dong
Liu, Feng
论文数: 0引用数: 0
h-index: 0
机构:
Univ Elect Sci & Technol China, Minist Educ, Sch Life Sci & Technol, Key Lab Neuroinformat, Chengdu 610054, Sichuan, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Liu, Feng
Xun, Guang-lei
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Mental Hlth Ctr, Jinan 250014, Shandong, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Xun, Guang-lei
Chen, Hua-fu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Elect Sci & Technol China, Minist Educ, Sch Life Sci & Technol, Key Lab Neuroinformat, Chengdu 610054, Sichuan, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Chen, Hua-fu
Hu, Mao-rong
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Hu, Mao-rong
Guo, Xiao-feng
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Guo, Xiao-feng
Xiao, Chang-qing
论文数: 0引用数: 0
h-index: 0
机构:
Guangxi Med Univ, Affiliated Hosp 1, Mental Hlth Ctr, Nanning 530021, Guangxi, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Xiao, Chang-qing
Wooderson, Sarah C.
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Inst Psychiat, Dept Psychol Med, London WC2R 2LS, EnglandCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Wooderson, Sarah C.
Guo, Wen-bin
论文数: 0引用数: 0
h-index: 0
机构:
Guangxi Med Univ, Affiliated Hosp 1, Mental Hlth Ctr, Nanning 530021, Guangxi, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Guo, Wen-bin
Zhao, Jing-ping
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
Hangzhou Seventh People Hosp, Hangzhou 310001, Zhejiang, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
机构:
NYU, Sch Med, Dept Child & Adolescent Psychiat, New York Child Study Ctr, New York, NY USAUniv Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA
机构:
NYU, Sch Med, Dept Child & Adolescent Psychiat, New York Child Study Ctr, New York, NY USA
Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USAUniv Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA
Gabbay, Vilma
Hulvershorn, Leslie
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Child & Adolescent Psychiat, New York Child Study Ctr, New York, NY USAUniv Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA
机构:
Univ Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA
Vet Adm Med Ctr, Minneapolis, MN 55417 USAUniv Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA
Lim, Kelvin O.
Castellanos, F. Xavier
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Child & Adolescent Psychiat, New York Child Study Ctr, New York, NY USA
Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USAUniv Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA
Castellanos, F. Xavier
Milham, Michael P.
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Child & Adolescent Psychiat, New York Child Study Ctr, New York, NY USAUniv Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA