Effect of Alpha-Fetoprotein on Differentiation of Myeloid Supressor Cells

被引：1
作者：
Zamorina, S. A. [1 ,2 ]
Shardina, K. Yu [1 ]
Timganova, V. P. [1 ]
Bochkova, M. S. [1 ,2 ]
Uzhviyuk, S., V [1 ]
Raev, M. B. [1 ,2 ]
Chereshnev, V. A. [1 ,2 ]
机构：
[1] Russian Acad Sci, PFIC Ural Branch, Inst Ecol & Genet Microorganisms, Ural Branch, Perm, Russia
[2] Perm State Natl Res Univ, Perm, Russia
来源：
DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2021年 / 501卷 / 01期
关键词：
alpha-fetoprotein (AFP); immune tolerance; myeloid-derived suppressor cells (MDSC); pregnancy; SUPPRESSOR-CELLS;
D O I：
10.1134/S1607672921060077
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of recombinant alpha-fetoprotein (AFP) on human myeloid suppressor cell (MDSC) differentiation was studied in vitro in the presence of cytokines IL-6 (10 ng/mL) and GM-CSF (10 ng/mL). It was found that AFP at concentrations of 50 and 100 IU/mL increased the number of MDSC (CD33(+) HLA-DR(-/low)CD11b(+)) in culture. Analysis of MDSC subpopulations showed that the increase was due to monocytic M-MDSC (HLA-DR(-/low)CD33(+)CD11b(+)CD14(+)CD66b(-)). There was no modulating effect of AFP on granulocytic PMN-MDSC (HLA-DR(-/low)CD33(+)CD11b(+)CD14(-)CD66b(+)). The effects of recombinant AFP on MDSC differentiation were thus demonstrated for the first time.
引用
收藏
页码：434 / 437
页数：4
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