Autophagy in tumorigenesis and cancer therapy: Dr. Jekyll or Mr. Hyde?

被引：111

作者：

Zhou, Shengtao ^{[1
,2
]}

Zhao, Linjie ^{[3
]}

Kuang, Manchao ^{[2
]}

Zhang, Bingjie ^{[2
]}

Liang, Zhu ^{[4
]}

Yi, Tao

Wei, Yuquan ^{[2
]}

Zhao, Xia ^{[1
]}

机构：

[1] Sichuan Univ, W China Hosp 2, Key Lab Obstet & Gynecol & Pediat Dis & Birth Def, Dept Gynecol & Obstet,Minist Educ, Chengdu 610041, Peoples R China

[2] Sichuan Univ, W China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

[3] Chengdu Univ, Coll Biotechnol & Ind, Chengdu 610041, Peoples R China

[4] Sichuan Univ, Coll Biol Sci, Chengdu 610041, Peoples R China

来源：

CANCER LETTERS | 2012年 / 323卷 / 02期

关键词：

Autophagy; Tumorigenesis; Cancer therapy; PROGRAMMED CELL-DEATH; TARGETING AUTOPHAGY; INDUCED APOPTOSIS; TUMOR-CELLS; INDUCED CYTOTOXICITY; KINASE INHIBITOR; IN-VITRO; PATHWAY; PROTEIN; BECLIN-1;

D O I：

10.1016/j.canlet.2012.02.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Autophagy is an evolutionarily conserved mechanism for intracellular substance degradation, responsible for the recycling of metabolic substances and the maintenance of intracellular stability. It has early been demonstrated to play a significant role in tumorigenesis, but whether it acts as a promoter or a suppressor during tumorigenesis seems to be context-specific. Moreover, autophagy is also implicated in promoting chemoresistance of cancer cells so as to attenuate therapeutic efficacy of chemotherapy. On the contrary, other reports highlight a tumor-killing role of autophagy during cancer treatment. Herein, this review aims to revisit the key features of autophagy, summarize the seemingly contradictory roles of autophagy during both tumorigenesis and cancer chemotherapy, and evaluate the feasibility of altering the level of cellular autophagy as part of cancer adjuvant treatment. (c) 2012 Published by Elsevier Ireland Ltd.

引用

页码：115 / 127

页数：13

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