Effect of UVB irradiation on microRNA expression in mouse epidermis

被引：12
|
作者：
Zhou, Bing-Rong [1 ]
Xu, Yang [1 ]
Luo, Dan [1 ]
机构：
[1] Nanjing Med Univ, Dept Dermatol, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China
来源：
ONCOLOGY LETTERS | 2012年 / 3卷 / 03期
基金：
中国国家自然科学基金;
关键词：
microRNA; microarray; ultraviolet radiation B; photodamage; DNA-DAMAGE RESPONSE; CANCER; GENE; APOPTOSIS; METHYLATION; REPAIR; CELLS;
D O I：
10.3892/ol.2012.551
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim of this study was to assess the effects of UVB irradiation on miRNA expression in the mouse epidermis. We determined miRNA expression profiles in the epidermis of UVB irradiated mice and untreated mice, and conducted Target Scan and Gene Ontology analyses to predict miRNA targets. Three miRNAs were downregulated and three were upregulated in the epidermis of UVB irradiated mice compared with untreated mice, and were predicted to be associated with photocarcinogenesis, hypomethylation and apoptosis. miRNAs are potentially involved in the pathogenesis of photodamage, and may aid in the treatment and prevention of UVB-induced dermatoses.
引用
收藏
页码：560 / 564
页数：5
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