Computational analysis of platelet adhesion and aggregation under stagnation point flow conditions

被引：7

作者：

Reininger, CB

Lasser, R

Rumitz, M

Böger, C

Schweiberer, L

机构：

[1] Univ Munich, Klinikum Innenstadt, Chirurg Klin & Poliklin, D-80366 Munich, Germany

[2] GSF, Natl Res Ctr Environm & Hlth, Inst Biomath & Biometry, Neuherberg, Germany

[3] Tech Univ Munich, Inst Anat, D-8000 Munich, Germany

来源：

COMPUTERS IN BIOLOGY AND MEDICINE | 1999年 / 29卷 / 01期

关键词：

stagnation point flow adhesio-aggregometry (SPAA); platelet adhesion; platelet aggregation; peripheral arterial disease (PAD); morphology; light intensity curve; mathematical model; K-pp; K-pw;

D O I：

10.1016/S0010-4825(98)00039-0

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The clinical relevance of platelet function assessment with stagnation point flow adhesio-aggregometry (SPAA) has been verified. Quantitative analysis of platelet adhesion and aggregation is possible by means of mathematical analysis of the dark-field, light intensity curves (growth curves) obtained during the SPAA experiment. We present a computational procedure for evaluating these curves, which was necessitated by, and is based on, actual clinical application. A qualitative growth curve classification, corresponding to a basic and distinct pattern of platelet deposition and characteristic of a regularly occurring clinical state is also presented. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1 / 18

页数：18

共 26 条

[1]

BAUMGARTNER HR, 1973, MICROVASC RES, V5, P67

[2]

DABROS T, 1987, PHYSICOCHEM HYDRODYN, V8, P161

[3] A DIRECT METHOD FOR STUDYING PARTICLE DEPOSITION ONTO SOLID-SURFACES [J].