Influence of Maternal Milk on the Neonatal Intestinal Microbiome

被引:102
|
作者
Gopalakrishna, Kathyayini P. [1 ]
Hand, Timothy W. [1 ]
机构
[1] Univ Pittsburgh, UPMC Childrens Hosp Pittsburgh, RK Mellon Inst Pediat Res, Pittsburgh, PA 15217 USA
基金
美国国家卫生研究院; 美国安德鲁·梅隆基金会;
关键词
maternal milk; breast milk; secretory IgA; neonatal microbiome; lactoferrin; human milk oligosaccharides; GUT MICROBIOTA; NECROTIZING ENTEROCOLITIS; SYMBIOTIC BACTERIA; EARLY-LIFE; SECRETORY ANTIBODIES; COLOSTRUM INTAKE; IGA; OLIGOSACCHARIDES; LACTOFERRIN; ENERGY;
D O I
10.3390/nu12030823
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The intestinal microbiome plays an important role in maintaining health throughout life. The microbiota develops progressively after birth and is influenced by many factors, including the mode of delivery, antibiotics, and diet. Maternal milk is critically important to the development of the neonatal intestinal microbiota. Different bioactive components of milk, such as human milk oligosaccharides, lactoferrin, and secretory immunoglobulins, modify the composition of the neonatal microbiota. In this article, we review the role of each of these maternal milk-derived bioactive factors on the microbiota and how this modulation of intestinal bacteria shapes health, and disease.
引用
收藏
页数:16
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