DW4TR: A Data Warehouse for Translational Research

被引：36

作者：

Hu, Hai ^{[1
]}

Correll, Mick ^{[3
]}

Kvecher, Leonid ^{[1
]}

Osmond, Michelle ^{[2
]}

Clark, Jim ^{[2
]}

Bekhash, Anthony ^{[1
]}

Schwab, Gwendolyn ^{[1
]}

Gao, De ^{[4
]}

Gao, Jun ^{[4
]}

Kubatin, Vladimir ^{[3
]}

Shriver, Craig D. ^{[5
]}

Hooke, Jeffrey A. ^{[5
]}

Maxwell, Larry G. ^{[5
]}

Kovatich, Albert J. ^{[6
]}

Sheldon, Jonathan G. ^{[2
]}

Liebman, Michael N. ^{[1
]}

Mural, Richard J. ^{[1
]}

机构：

[1] Windber Res Inst, Windber, PA 15963 USA

[2] InforSense LLC, London, England

[3] InforSense Ltd, Boston, MA USA

[4] InforSense Ltd, Shanghai, Peoples R China

[5] Walter Reed Army Med Ctr, Washington, DC 20307 USA

[6] MDR Global, Windber, PA USA

来源：

JOURNAL OF BIOMEDICAL INFORMATICS | 2011年 / 44卷 / 06期

关键词：

Data Warehouse; Translational research; Patient-centric data model; User interface; Ontology; PATHOLOGISTS GUIDELINE RECOMMENDATIONS; CLINICAL-RESEARCH; BIOMEDICAL INFORMATICS; INTEGRATING BIOLOGY; AMERICAN-SOCIETY; CANCER; ONTOLOGY; QUERY; TOOL; IMPLEMENTATION;

D O I：

10.1016/j.jbi.2011.08.003

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

The linkage between the clinical and laboratory research domains is a key issue in translational research. Integration of clinicopathologic data alone is a major task given the number of data elements involved. For a translational research environment, it is critical to make these data usable at the point-of-need. Individual systems have been developed to meet the needs of particular projects though the need for a generalizable system has been recognized. Increased use of Electronic Medical Record data in translational research will demand generalizing the system for integrating clinical data to support the study of a broad range of human diseases. To ultimately satisfy these needs, we have developed a system to support multiple translational research projects. This system, the Data Warehouse for Translational Research (DW4TR), is based on a light-weight, patient-centric modularly-structured clinical data model and a specimen-centric molecular data model. The temporal relationships of the data are also part of the model. The data are accessed through an interface composed of an Aggregated Biomedical-Information Browser (ABB) and an Individual Subject Information Viewer (ISIV) which target general users. The system was developed to support a breast cancer translational research program and has been extended to support a gynecological disease program. Further extensions of the DW4TR are underway. We believe that the DW4TR will play an important role in translational research across multiple disease types. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：1004 / 1019

页数：16

共 83 条

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