Asymmetric Synthesis of P-Stereogenic Phosphinic Amides via Pd(0)-Catalyzed Enantioselective Intramolecular C-H Arylation

被引：112

作者：

Liu, Lantao ^{[1
]}

Zhang, An-An

Wang, Yanfang ^{[2
]}

Zhang, Fuqiang ^{[1
]}

Zuo, Zhenzhen ^{[1
]}

Zhao, Wen-Xian ^{[1
]}

Feng, Cui-Lan ^{[1
]}

Ma, Wenjin ^{[2
]}

机构：

[1] Shangqiu Normal Univ, Coll Chem & Chem Engn, Shangqiu 476000, Henan, Peoples R China

[2] Shanxi Normal Univ, Sch Chem & Mat Sci, Linfen 041004, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 09期

基金：

中国国家自然科学基金;

关键词：

CHIRAL PHOSPHORUS LIGANDS; COUPLING REACTIONS; INDOLINES; MECHANISM; OXIDES; DEPROTONATION; FERROCENES; ACCESS; SCOPE; HYDROPHOSPHINATION;

D O I：

10.1021/acs.orglett.5b00122

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The palladium-catalyzed enantioselective intramolecular C-H arylation of N-(2-haloaryl)-P,P-diphenylphosphinic amides furnishes P-stereogenic phosphine oxide derivatives in 61-99% yield with 88-97% ee. The catalyst generated in situ from a TADDOL-derived phosphoramide ligand and Pd(dba)(2) is optimum in terms of yield and enantioselectivities.

引用

页码：2046 / 2049

页数：4

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