Therapeutic use of transferrin to modulate anemia and conditions of iron toxicity

被引:29
作者
Boshuizen, M. [1 ,2 ,3 ]
van der Ploeg, K. [1 ]
von Bonsdorff, L. [4 ]
Biemond, B. J. [5 ]
Zeerleder, S. S. [3 ,5 ,6 ]
van Bruggen, R. [2 ,3 ]
Juffermans, N. P. [1 ]
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Intens Care Med, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Dept Blood Cell Res, Sanquin Res, Plesmanlaan 125, NL-1066 CX Amsterdam, Netherlands
[3] Univ Amsterdam, Acad Med Ctr, Landsteiner Lab, Plesmanlaan 125, NL-1066 CX Amsterdam, Netherlands
[4] Sanquin Oy, Hevosenkenka 3, Espoo 02600, Finland
[5] Univ Amsterdam, Acad Med Ctr, Dept Hematol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands
[6] Univ Amsterdam, Acad Med Ctr, Dept Immunopathol, Sanquin Res, NL-1066 CX Amsterdam, Netherlands
关键词
Transferrin therapy; Anemia; Hypotransferrinemia; beta-thalassemia; Oxidative stress; Non-transferrin bound iron; ISCHEMIA-REPERFUSION INJURY; BONE-MARROW; CELL TRANSPLANTATION; PEPTIDE HEPCIDIN; BOUND IRON; APOTRANSFERRIN; OVERLOAD; GENE; HEMOCHROMATOSIS; ERYTHROFERRONE;
D O I
10.1016/j.blre.2017.07.005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
As the main iron transporter, transferrin delivers iron to target tissues like the bone marrow for erythropoiesis. Also, by binding free iron, transferrin prevents formation of reactive oxygen species. Transferrin deficiency due to congenital hypotransferrinemia is characterized by anemia as well as oxidative stress related to toxic free iron. Transfersin supplementation may be beneficial in two ways. First, transferrin can correct anemia by modulating the amount of iron that is available for erythropoiesis. This is obvious for patients that suffer from hypotransferrinemia, but may also have beneficial effects for beta-thalassemia patients. Second, under conditions of iron overload, transferrin reduces oxidative stress by binding free iron in the circulation and in tissues. Hereby, transferrin protects the host against the reactive oxygen species that can be formed as a consequence of free iron. This beneficial effect is shown in hematological patients undergoing chemotherapy and stem cell transplantation. Transferrin may also be beneficial in lung injury, ischemia-reperfusion injury and hypomyelination. This review summarizes the preclinical and clinical data on the efficacy of exogenous transferrin administration to modulate certain forms of anemia and to prevent the toxic effects of free iron. Thereby, we show that transferrin has promising therapeutic potential in a wide variety of conditions.
引用
收藏
页码:400 / 405
页数:6
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