pH-Sensitive mesoporous silica nanoparticles for chemo-photodynamic combination therapy

被引：38
作者：
Yan, Tingsheng [1 ]
Cheng, Jinju [2 ]
Liu, Zongjun [1 ]
Cheng, Feng [1 ]
Wei, Xinjing [1 ]
He, Jinmei [1 ]
机构：
[1] Harbin Inst Technol, MIIT Key Lab Crit Mat Technol New Energy Convers, State Key Lab Urban Water Resource & Environm, Sch Chem & Chem Engn, Harbin 150010, Heilongjiang, Peoples R China
[2] Northeast Agr Univ, Food Sci Coll, Harbin 150030, Heilongjiang, Peoples R China
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2018年 / 161卷
关键词：
pH-Sensitive; Chemo-photodynamic therapy; Mesoporous silica nanoparticle; Rose bengal; Doxorubicin; DRUG-RESISTANCE; TARGETED DELIVERY; RELEASE; CANCER; GATEKEEPERS; CARRIER; SYSTEM;
D O I：
10.1016/j.colsurfb.2017.11.006
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
In order to optimize the chemotherapeutic efficacy of doxorubicin (DOX) and improve the photodynamic therapeutic effectiveness of rose bengal (RB), a mesoporous silica nanoparticle system was designed as the carrier of RB and DOX for chemo-photodynamic combination therapy. A pH-sensitive strategy has been exploited to enhance the delivery efficiency. Our results suggested that the production of singlet oxygen was independent of the release of RB while strongly influenced by the external DOX layer. This method showed several benefits, including accelerating cellular uptake of the payloads and enabling chemo-photodynamic combination therapy for synergistic cancer treatment. Our study provides a new way for co-delivery of chemotherapy agents and photosensitizers. (C) 2017 Published by Elsevier B.V.
引用
收藏
页码：442 / 448
页数：7
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