Daminin, a bioactive pyrrole alkaloid from the Mediterranean sponge Axinella damicornis

被引：25
作者：
Aiello, A
D'Esposito, M
Fattorusso, E
Menna, M
Müller, WEG
Perovic-Ottstadt, S
Tsuruta, H
Gulder, TAM
Bringmann, G
机构：
[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy
[2] Univ Mainz, Inst Physiol Chem, Angew Mol Biol Abt, D-55099 Mainz, Germany
[3] Univ Wurzburg, Inst Organ Chem, D-97070 Wurzburg, Germany
来源：
TETRAHEDRON | 2005年 / 61卷 / 30期
关键词：
marine natural products; sponges; pyrrole alkaloids; total synthesis;
D O I：
10.1016/j.tet.2005.05.025
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The isolation and characterization of the known pyrrole alkaloid agelongine (6) and of the new natural product daminin (7), the bromine-free analogue of 6, from a specimen of the marine sponge Axinella damicornis is described. Compound 7 showed significant neuroprotective properties. Moreover, for the supply of sufficient material for future medicinal investigations, a short total synthesis of 7 was developed. (c) 2005 Published by Elsevier Ltd.
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收藏
页码：7266 / 7270
页数：5
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