Synthesis of novel potent DPP-IV inhibitors with enhanced chemical stability: Interplay between the alkyl fragment of the N-terminal amino acid moiety and the cyclopropyl group of alpha-aminoacyl-(L)-(cis)-4,5-methanoprolinenitrile-based inhibitors.

被引：0

作者：

Magnin, D

Robl, J

Sulsky, RB

Augieri, DJ

Huang, Y

Taunk, P

Betebenner, DA

Simpkins, LM

Robertson, JG

Khanna, A

Abboa-Offei, B

Wang, AY

Cap, M

Xing, L

Tao, L

Sitkoff, D

Malley, M

Gougoutas, J

Huang, Q

Han, SP

Parker, RA

Hamann, LG

机构：

[1] Bristol Myers Squibb Co, Discovery Chem, Princeton, NJ 08543 USA

[2] Bristol Myers Squibb Co, Dept Metab Res, Princeton, NJ 08543 USA

[3] Bristol Myers Squibb Co, Dept Preclin Candidate Optimizat, Princeton, NJ 08543 USA

[4] Bristol Myers Squibb Co, Dept Exploratory Pharmaceut, Princeton, NJ 08543 USA

[5] Bristol Myers Squibb Co, Dept Comp Aided Drug Design, Princeton, NJ 08543 USA

[6] Bristol Myers Squibb Co, Dept Crystallog, Princeton, NJ 08543 USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 225卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

189-MEDI

引用

页码：U207 / U207

页数：1