Lewis Acid Mediated One-Pot Synthesis of Aryl/Heteroaryl-Fused Carbazoles Involving a Cascade Friedel-Crafts Alkylation/Electrocyclization/Aromatization Reaction Sequence

被引：39

作者：

Sureshbabu, Radhakrishnan ^{[1
]}

Saravanan, Velu ^{[1
]}

Dhayalan, Vasudevan ^{[1
]}

Mohanakrishnan, Arasambattu K. ^{[1
]}

机构：

[1] Univ Madras, Dept Organ Chem, Madras 600025, Tamil Nadu, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 05期

关键词：

Domino reactions; Friedel-Crafts reactions; Electrocyclization; Annulation; Fused ring systems; BIOLOGICAL EVALUATION; FACILE SYNTHESIS; GENERAL-METHOD; CONSTRUCTION; CYCLIZATION; INDOLES; ELLIPTICINE; DERIVATIVES; ANNULATION; ARYLATION;

D O I：

10.1002/ejoc.201001309

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Lewis-acid-mediated domino reaction of 2/3-(bromomethyl)indoles with arenes/heteroarenes led to the formation of the corresponding annulated carbazoles. This three-step one-pot transformation proceeds by sequential Lewis acid catalysed Friedel-Crafts alkylation, electrocyclization and aromatization reactions. The strategy is highly efficient for the assembly of complex aryl/heteroaryl-fused carbazoles.

引用

页码：922 / 935

页数：14

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