Cu-Catalyzed Radical Cascade Annulations of Alkyne-Tethered N-Alkoxyamides with Air: Facile Access to Isoxazolidine/1,2-Oxazinane-Fused Isoquinolin-1(2H)-ones

被引：51

作者：

Chen, Fei ^{[1
]}

Lai, Sheng-Qiang ^{[1
]}

Zhu, Fei-Fei ^{[1
]}

Meng, Qiang ^{[1
]}

Jiang, Yu ^{[1
]}

Yu, Wei ^{[1
]}

Han, Bing ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

来源：

ACS CATALYSIS | 2018年 / 8卷 / 09期

基金：

中国国家自然科学基金;

关键词：

copper/air catalytic system; cascade annulation; isoquinolin-1(2H)-one; isoxazolidine; 1,2-oxazinane; RHODIUM(III)-CATALYZED INTRAMOLECULAR ANNULATION; H BOND FUNCTIONALIZATION; ELECTROCHEMICAL SYNTHESIS; OXIDATIVE CYCLOADDITION; ISOQUINOLONE SYNTHESIS; EFFICIENT SYNTHESIS; MOLECULAR-OXYGEN; ACTIVATION; ALKENES; CYCLIZATION;

D O I：

10.1021/acscatal.8b02445

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A series of structurally important isoxazolidine/1,2-oxazinane-fused isoquinolin-1(2H)-ones have been facilely synthesized via efficient Cu-catalyzed aerobic oxidative radical cascade annulations of alkyne-tethered N-alkoxyamides. This method features air as the environment-friendly oxidant and has the merits of a cheap catalyst, broad substrates scope, high atom economy, and simple operation.

引用

页码：8925 / 8931

页数：13

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