ATF2 on the double - activating transcription factor and DNA damage response protein

被引：80

作者：

Bhoumik, Anindita ^{[1
]}

Lopez-Bergami, Pablo ^{[1
]}

Ronai, Ze'ev ^{[1
]}

机构：

[1] Burke Med Res Inst, Signal Transduc Program, La Jolla, CA USA

来源：

PIGMENT CELL RESEARCH | 2007年 / 20卷 / 06期

关键词：

ATF2; transcription; DNA damage; stress response; hypoxia; skin cancer; melanoma;

D O I：

10.1111/j.1600-0749.2007.00414.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Signal transduction pathways play a key role in the regulation of key cellular processes, including survival and death. Growing evidence points to changes in signaling pathway that occur during skin tumor development and progression. Such changes impact the activity of downstream substrates, including transcription factors. The activating transcription factor 2 (ATF2) has been implicated in malignant and non-malignant skin tumor developments. ATF2 mediates both transcription and DNA damage control, through its phosphorylation by JNK/p38 or ATM/ATR respectively. Here, we summarize our present understanding of ATF2 regulation, function and contribution to malignant and non-malignant skin tumor development.

引用

页码：498 / 506

页数：9

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