The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells

被引:15
作者
Zhang, Linlin [1 ,2 ]
Qi, Jingyi [2 ]
Zhang, Xu [2 ]
Zhao, Xiya [2 ]
An, Peng [2 ]
Luo, Yongting [2 ]
Luo, Junjie [2 ]
机构
[1] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100083, Peoples R China
[2] China Agr Univ, Dept Nutr & Hlth, Key Lab Precis Nutr & Food Qual, Beijing 100193, Peoples R China
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
mitochondrial calcium; calcium homeostasis; calcium regulation; MCU; tumor; ENDOPLASMIC-RETICULUM; CA2+ INFLUX; HEPATOCELLULAR-CARCINOMA; CANCER-CELLS; MCU COMPLEX; APOPTOSIS; HOMEOSTASIS; AUTOPHAGY; RECEPTOR; TRANSPORT;
D O I
10.3390/ijms23126667
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mitochondria, as the main site of cellular energy metabolism and the generation of oxygen free radicals, are the key switch for mitochondria-mediated endogenous apoptosis. Ca2+ is not only an important messenger for cell proliferation, but it is also an indispensable signal for cell death. Ca2+ participates in and plays a crucial role in the energy metabolism, physiology, and pathology of mitochondria. Mitochondria control the uptake and release of Ca2+ through channels/transporters, such as the mitochondrial calcium uniporter (MCU), and influence the concentration of Ca2+ in both mitochondria and cytoplasm, thereby regulating cellular Ca2+ homeostasis. Mitochondrial Ca2+ transport-related processes are involved in important biological processes of tumor cells including proliferation, metabolism, and apoptosis. In particular, MCU and its regulatory proteins represent a new era in the study of MCU-mediated mitochondrial Ca2+ homeostasis in tumors. Through an in-depth analysis of the close correlation between mitochondrial Ca2+ and energy metabolism, autophagy, and apoptosis of tumor cells, we can provide a valuable reference for further understanding of how mitochondrial Ca2+ regulation helps diagnosis and therapy.
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页数:19
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