Beyond a Carrier: Graphene Quantum Dots as a Probe for Programmatically Monitoring Anti-Cancer Drug Delivery, Release, and Response

被引：100

作者：

Ding, Hui ^{[1
]}

Zhang, Fan ^{[3
]}

Zhao, Chaochao ^{[2
]}

Lv, Yanlin ^{[1
]}

Ma, Guanghui ^{[2
]}

Wei, Wei ^{[2
]}

Tian, Zhiyuan ^{[1
]}

机构：

[1] Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China

[2] Chinese Acad Sci, Inst ProcessEngn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China

[3] Hebei Normal Univ Sci & Technol, Life Sci & Technol Inst, Qinhuangdao 066004, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2017年 / 9卷 / 33期

基金：

中国国家自然科学基金;

关键词：

graphene quantum dots; cathepsin D-responsive; fluorescence quenching; theranostic; CANCER-DIAGNOSIS; FLUORESCENT; NANOPARTICLES; THERAPY;

D O I：

10.1021/acsami.7b08824

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

On the basis of the unique physicochemical properties of graphene quantum dots (GQDs), we developed a novel type of theranostic agent by loading anticancer drug doxorubicin (DOX) to GQD's surface and conjugating Cy5.5 (Cy) dye to GQD though a cathepsin D-responsive (P) peptide. Such type of agents demonstrated superior therapeutic performance both in vitro and in vivo because of the improved tissue penetration and cellular uptake. More importantly, they are capable of functioning as probes for programmed tracking the delivery and release of anticancer drug as well as drug induced cancer cell apoptosis through GQD's, DOX's, and Cy's charateristic fluorescence, respectively.

引用

页码：27396 / 27401

页数：6

共 30 条

[1]

[Anonymous], 2012, J PHYS PHARM ADV J P

[2] In Vivo Fluorescence Lifetime Imaging for Monitoring the Efficacy of the Cancer Treatment [J].

Ardeshirpour, Yasaman ;

Chernomordik, Victor ;

Hassan, Moinuddin ;

Zielinski, Rafal ;

Capala, Jacek ;

Gandjbakhche, Amir .

CLINICAL CANCER RESEARCH, 2014, 20 (13) :3531-3539

[3] Nanomaterials: Applications in Cancer Imaging and Therapy [J].

Barreto, Jose A. ;

O'Malley, William ;

Kubeil, Manja ;

Graham, Bim ;

Stephan, Holger ;

Spiccia, Leone .

ADVANCED MATERIALS, 2011, 23 (12) :H18-H40

[4] Unusual emission transformation of graphene quantum dots induced by self-assembled aggregation [J].

Chen, Shuai ;

Liu, Jia-Wei ;

Chen, Mei-Ling ;

Chen, Xu-Wei ;

Wang, Jian-Hua .

CHEMICAL COMMUNICATIONS, 2012, 48 (61) :7637-7639

[5] Fluorescent, Superparamagnetic Nanospheres for Drug Storage, Targeting, and Imaging: A Multifunctional Nanocarrier System for Cancer Diagnosis and Treatment [J].

Cho, Hoon-Sung ;

Dong, Zhongyun ;

Pauletti, Giovanni M. ;

Zhang, Jiaming ;

Xu, Hong ;

Gu, Hongchen ;

Wang, Lumin ;

Ewing, Rodney C. ;

Huth, Christopher ;

Wang, Feng ;

Shi, Donglu .

ACS NANO, 2010, 4 (09) :5398-5404

[6] pH-Responsive fluorescent graphene quantum dots for fluorescence-guided cancer surgery and diagnosis [J].

Fan, Zetan ;

Zhou, Shixin ;

Garcia, Cesar ;

Fan, Louzhen ;

Zhou, Jiangbing .

NANOSCALE, 2017, 9 (15) :4928-4933

[7] Cancer nanotechnology: Opportunities and challenges [J].

Ferrari, M .

NATURE REVIEWS CANCER, 2005, 5 (03) :161-171

[8] Spheroid-based drug screen: considerations and practical approach [J].

Friedrich, Juergen ;

Seidel, Claudia ;

Ebner, Reinhard ;

Kunz-Schughart, Leoni A. .

NATURE PROTOCOLS, 2009, 4 (03) :309-324

[9] Light-Triggered Theranostics Based on Photosensitizer-Conjugated Carbon Dots for Simultaneous Enhanced-Fluorescence Imaging and Photodynamic Therapy [J].

Huang, Peng ;

Lin, Jing ;

Wang, Xiansong ;

Wang, Zhe ;

Zhang, Chunlei ;

He, Meng ;

Wang, Kan ;

Chen, Feng ;

Li, Zhiming ;

Shen, Guangxia ;

Cui, Daxiang ;

Chen, Xiaoyuan .

ADVANCED MATERIALS, 2012, 24 (37) :5104-5110

[10]

Jemal A, 2009, CA-CANCER J CLIN, V59, P225, DOI [10.3322/caac.20006, 10.3322/caac.21254, 10.3322/caac.21332, 10.3322/caac.21551, 10.3322/caac.20073, 10.3322/caac.21387, 10.3322/caac.21654, 10.3322/caac.21601]

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