Making a zebrafish kidney: a tale of two tubes

被引：87
作者：
Drummond, I
机构：
[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Med, Charlestown, MA 02129 USA
[2] Massachusetts Gen Hosp, Renal Unit, Charlestown, MA 02129 USA
来源：
TRENDS IN CELL BIOLOGY | 2003年 / 13卷 / 07期
关键词：
D O I：
10.1016/S0962-8924(03)00124-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The kidney can be thought of as the pairing of two tubes: an epithelial tube (the nephron), carrying filtered blood and engaged in ion and water transport; and endothelial tubes (the blood vessels), delivering blood and carrying away recovered solute. The development of the nephron presents several interesting questions. How does an epithelial tube form and how is it patterned into functionally distinct components and segments? What guides the interaction between the vasculature and kidney epithelia? How are epithelial cell shape and lumen diameter maintained, and what goes wrong when kidney tubules balloon into cysts? Here, I outline the progress that has been made in answering these questions using the zebrafish pronephros as a simple, accessible model of nephron development.
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页码：357 / 365
页数：9
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