CD8-positive T cell-induced liver damage was found in a patient with polymyositis

被引：2
|
作者：
Takahashi, Atsushi [1 ]
Takeda, Isao [1 ]
Kanno, Takashi [1 ]
Nakahara, Toshiki [2 ]
Odajima, Hajime [3 ]
Kasukawa, Reiji [1 ]
机构：
[1] Ohta Nishinouchi Hosp, Div Rheumatol, Koriyama, Fukushima, Japan
[2] Ohta Nishinouchi Hosp, Div Neurol, Koriyama, Fukushima, Japan
[3] Ohta Nishinouchi Hosp, Div Pathol, Koriyama, Fukushima, Japan
来源：
INTERNAL MEDICINE | 2006年 / 45卷 / 18期
关键词：
polymyositis; liver disturbance; CD8-positive T cell; IVIG;
D O I：
10.2169/internalmedicine.45.1710
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We describe a case of polymyositis (PM) with liver injury that occurred in a patient with rheumatoid arthritis (RA). A 74-year-old woman who had a 12-year history of RA was admitted to our hospital because of muscle weakness and liver dysfunction. CD8-positive T cell infiltration was found in the interstitium of both the liver and muscle. In addition to the administration of a large amount of prednisolone (PSL), high-dose intravenous immunoglobulin (IVIG) successfully improved myositis and hepatitis. Our case indicates the pathogenic potential of CD8-positive T cells in PM-associated liver injury.
引用
收藏
页码：1059 / 1063
页数：5
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