CD8-positive T cell-induced liver damage was found in a patient with polymyositis

被引：2

作者：

Takahashi, Atsushi ^{[1
]}

Takeda, Isao ^{[1
]}

Kanno, Takashi ^{[1
]}

Nakahara, Toshiki ^{[2
]}

Odajima, Hajime ^{[3
]}

Kasukawa, Reiji ^{[1
]}

机构：

[1] Ohta Nishinouchi Hosp, Div Rheumatol, Koriyama, Fukushima, Japan

[2] Ohta Nishinouchi Hosp, Div Neurol, Koriyama, Fukushima, Japan

[3] Ohta Nishinouchi Hosp, Div Pathol, Koriyama, Fukushima, Japan

来源：

INTERNAL MEDICINE | 2006年 / 45卷 / 18期

关键词：

polymyositis; liver disturbance; CD8-positive T cell; IVIG;

D O I：

10.2169/internalmedicine.45.1710

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe a case of polymyositis (PM) with liver injury that occurred in a patient with rheumatoid arthritis (RA). A 74-year-old woman who had a 12-year history of RA was admitted to our hospital because of muscle weakness and liver dysfunction. CD8-positive T cell infiltration was found in the interstitium of both the liver and muscle. In addition to the administration of a large amount of prednisolone (PSL), high-dose intravenous immunoglobulin (IVIG) successfully improved myositis and hepatitis. Our case indicates the pathogenic potential of CD8-positive T cells in PM-associated liver injury.

引用

页码：1059 / 1063

页数：5

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