A near-infrared fluorescent probe for fluorine ions and its application in the imaging of HepG2 cells

被引：11

作者：

Gong, Wei ^{[1
]}

Su, RuiXian ^{[1
]}

Li, Lu ^{[1
]}

Xu, KeHua ^{[1
]}

Tang, Bo ^{[1
]}

机构：

[1] Shandong Normal Univ, Key Lab Mol & Nano Probes, Engn Res Ctr Pesticide & Med Intermediate Clean P, Coll Chem Chem Engn & Mat Sci,Minist Educ, Jinan 250014, Peoples R China

来源：

CHINESE SCIENCE BULLETIN | 2011年 / 56卷 / 31期

基金：

中国国家自然科学基金; 国家杰出青年科学基金;

关键词：

near infrared; fluorescent probe; fluorine ion; BODIPY; ACID;

D O I：

10.1007/s11434-011-4662-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this study, we have designed and synthesized a new near-infrared (NIR) fluorescent probe (BODIPY-Se) to detect fluorine ions (F-) using a B-Se bond to connect the fluorescent dye BODIPY and benzotrifluoride. The probe exhibited a highly selective fluorescence response to F. with a detection limit of 7.4 x 10(-8) mol/L. The excitation and emission spectra of the probe in the NIR region avoid background fluorescence interference present in biological systems. The fluorescent imaging of HepG2 cells demonstrated that the newly developed probe should be broadly applicable to detect F. in living cells.

引用

页码：3260 / 3265

页数：6

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