miR-215 overexpression distinguishes ampullary carcinomas from pancreatic carcinomas

被引：13

作者：

Choi, Dong Ho ^{[1
]}

Park, Sang Jae ^{[2
]}

Kim, Hark Kyun ^{[3
]}

机构：

[1] Hanyang Univ, Sch Med, Dept Surg, Seoul 133791, South Korea

[2] Natl Canc Ctr, Ctr Liver Canc, Goyang 410769, Gyeonggi, South Korea

[3] Natl Canc Ctr, Biomol Funct Res Branch, Goyang 410769, Gyeonggi, South Korea

来源：

HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL | 2015年 / 14卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

ampulla of Vater; pancreatic cancer; gene expression; MICRORNA; VATER;

D O I：

10.1016/S1499-3872(15)60368-X

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Distinguishing arnpullary carcinoma from pancreatic carcinoma is important because of their different prognoses. microRNAs are differentially expressed according to the tissue of origin. However, there is rare research on the differential diagnosis between the two types of cancers by microRNA in periampullary cancers. The present study was undertaken to compare microRNA profiles between ampullary and pancreatic carcinomas using microarrays. miR-215 was most significantly overexpressed in ampullary carcinomas; whereas the expressions of miR-134 and miR-214 were significantly lower in ampullary carcinomas than in pancreatic carcinomas. When these discriminatory microRNAs were applied to liver metastases, they were correctly predicted for the tissue of origin. Although this study is limited by small sample size, striking difference in microRNA expression and concordant expression of discriminating microRNAs in primary tumors and metastases suggest that these novel discriminatory microRNAs warrant future validation.

引用

页码：325 / 329

页数：5

共 8 条

[1] p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest [J].