Safety profiles of erlotinib therapy in patients with advanced non-small-cell lung cancer

被引：1

作者：

Hotta, Katsuyuki ^{[1
]}

Kiura, Katsuyuki ^{[1
]}

机构：

[1] Okayama Univ Hosp, Dept Resp Med, Kita Ku, Okayama 7008558, Japan

来源：

EXPERT REVIEW OF ANTICANCER THERAPY | 2011年 / 11卷 / 07期

关键词：

elrotinib; non-small-cell lung cancer; toxicity; GROWTH-FACTOR RECEPTOR; TYROSINE KINASE INHIBITOR; PHASE-III TRIAL; PREVIOUSLY TREATED PATIENTS; JAPANESE PATIENTS; CLINICAL-SIGNIFICANCE; PRACTICAL MANAGEMENT; EGFR MUTATIONS; GENE-MUTATIONS; SKIN RASH;

D O I：

10.1586/ERA.11.74

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Erlotinib is an orally available, small-molecule EGF receptor tyrosine kinase inhibitor. It has shown promising activity in chemotherapy-relapsed patients with advanced non-small-cell lung cancer and is now approved in many countries. To date, there have been a number of clinical studies of erlotinib therapy demonstrating its safety as well as its efficacy. This article summarizes clinical study results in advanced non-small-cell lung cancer, so that we can comprehensively understand the toxicities expected with erlotinib in non-small-cell lung cancer patients.

引用

页码：991 / 997

页数：7

共 57 条

[41] EGFR mutations in lung cancer:: Correlation with clinical response to gefitinib therapy [J].

Paez, JG ;

Jänne, PA ;

Lee, JC ;

Tracy, S ;

Greulich, H ;

Gabriel, S ;

Herman, P ;

Kaye, FJ ;

Lindeman, N ;

Boggon, TJ ;

Naoki, K ;

Sasaki, H ;

Fujii, Y ;

Eck, MJ ;

Sellers, WR ;

Johnson, BE ;

Meyerson, M .

SCIENCE, 2004, 304 (5676) :1497-1500

[42] HER1/EGFR inhibitor-associated rash:: Future directions for management and investigation outcomes from the HER1/EGFR inhibitor rash management forum [J].

Pérez-Soler, R ;

Delord, JP ;

Halpern, A ;

Kelly, K ;

Krueger, J ;

Suresa, BM ;

von Pawel, J ;

Temel, J ;

Siena, S ;

Soulières, D ;

Saltz, L ;

Leyden, J .

ONCOLOGIST, 2005, 10 (05) :345-356

[43] Determinants of tumor response and survival with erlotinib in patients with non-small-cell lung cancer [J].

Pérez-Soler, R ;

Chachoua, A ;

Hammond, LA ;

Rowinsky, EK ;

Huberman, M ;

Karp, D ;

Rigas, J ;

Clark, GM ;

Santabàrbara, P ;

Bonomi, P .

JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (16) :3238-3247

[44] The Role of EGFR Inhibition in the Treatment of Non-Small Cell Lung Cancer [J].

Ray, Mandira ;

Salgia, Ravi ;

Vokes, Everett E. .

ONCOLOGIST, 2009, 14 (11) :1116-1130

[45] Erlotinib in Advanced Non-small Cell Lung Cancer Efficacy and Safety Findings of the Global Phase IV Tarceva Lung Cancer Survival Treatment Study [J].

Reck, Martin ;

van Zandwijk, Nico ;

Gridelli, Cesare ;

Baliko, Zoltan ;

Rischin, Danny ;

Allan, Simon ;

Krzakowski, Maciej ;

Heigener, David .

JOURNAL OF THORACIC ONCOLOGY, 2010, 5 (10) :1616-1622

[46] Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer. [J].

Rosell, Rafael ;

Moran, Teresa ;

Queralt, Cristina ;

Porta, Rut ;

Cardenal, Felipe ;

Camps, Carlos ;

Majem, Margarita ;

Lopez-Vivanco, Guillermo ;

Isla, Dolores ;

Provencio, Mariano ;

Insa, Amelia ;

Massuti, Bartomeu ;

Luis Gonzalez-Larriba, Jose ;

Paz-Ares, Luis ;

Bover, Isabel ;

Garcia-Campelo, Rosario ;

Angel Moreno, Miguel ;

Catot, Silvia ;

Rolfo, Christian ;

Reguart, Noemi ;

Palmero, Ramon ;

Miguel Sanchez, Jose ;

Bastus, Roman ;

Mayo, Clara ;

Bertran-Alamillo, Jordi ;

Angel Molina, Miguel ;

Javier Sanchez, Jose ;

Taron, Miquel .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (10) :958-U38

[47] Randomized double-blind trial of prophylactic oral minocycline and topical tazarotene for cetuximab-associated acne-like eruption [J].

Scope, Alon ;

Agero, Anna Liza C. ;

Dusza, Stephen W. ;

Myskowski, Patricia L. ;

Lieb, Jocelyn A. ;

Saltz, Leonard ;

Kemeny, Nancy E. ;

Halpern, Allan C. .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (34) :5390-5396

[48]

Shepherd FA, 2005, N ENGL J MED, V353

[49] Epidermal growth factor receptor mutation status and adjuvant chemotherapy with uracil-tegafur for adenocarcinoma of the lung [J].

Suehisa, Hiroshi ;

Toyooka, Shinichi ;

Hotta, Katsuyuki ;

Uchida, Akiko ;

Soh, Junichi ;

Fujiwara, Yoshiro ;

Matsuo, Keitaro ;

Ouchida, Mamoru ;

Takata, Minoru ;

Kiura, Katsuyuki ;

Date, Hiroshi .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (25) :3952-3957

[50]

Takahashi T, 2010, ANTICANCER RES, V30, P557

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