Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine

被引：53

作者：

Khamdang, S

Takeda, M

Shimoda, M

Noshiro, R

Narikawa, S

Huang, XL

Enomoto, A

Piyachaturawat, P

Endou, H ^{[1
]}

机构：

[1] Kyorin Univ, Sch Med, Dept Pharmacol & Toxicol, Tokyo 1818611, Japan

[2] Mahidol Univ, Fac Sci, Dept Physiol, Bangkok 10400, Thailand

[3] Tokyo Univ Agr & Technol, Fac Agr, Dept Vet Med, Tokyo 1830054, Japan

[4] Fuji Biomedixs Co, Kobuchizawa Labs, Yamanashi 4080044, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2004年 / 94卷 / 02期

关键词：

organic anion transporter; pravastatin; cimetidine;

D O I：

10.1254/jphs.94.197

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have elucidated the interactions of human and rat organic anion transporters (hOATs and rOATs) with pravastatin and cimetidine. Pravastatin inhibited hOAT1/rOAT1, hOAT2/rOAT2, hOAT3/rOAT3, and hOAT4. The mode of inhibition was noncompetitive for hOAT1 and hOAT2, whereas it was competitive for hOAT3 and hOAT4. Cimetidine also inhibited hOAT1/rOAT1, hOAT3 /rOAT3, and hOAT4. The mode of inhibition was a combination of competitive and noncompetitive manners for hOAT1, whereas it was competitive for hOAT3. The effects of OAT inhibitors on OAT1, OAT2, and OAT3 exhibited some but not so remarkable interspecies differences between humans and rats. In conclusion, we have characterized pravastatin and cimetidine as OAT inhibitors.

引用

页码：197 / 202

页数：6

共 17 条

[1] Role of human organic anion transporter 4 in the transport of ochratoxin A
Babu, E
Takeda, M
Narikawa, S
Kobayashi, Y
Enomoto, A
Tojo, A
Cha, SH
Sekine, T
Sakthisekaran, D
Endou, H
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2002, 1590 (1-3): : 64 - 75
[2] BIRNBAUM J, 1985, AM J MED, V78, P3, DOI 10.1016/0002-9343(85)90097-X
[3] Transport of cimetidine by flounder and human renal organic anion transporter 1
Burckhardt, BC
Brai, S
Wallis, S
Krick, W
Wolff, NA
Burckhardt, G
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2003, 284 (03) : F503 - F509
[4] Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney
Cha, SH
Sekine, T
Fukushima, J
Kanai, Y
Kobayashi, Y
Goya, T
Endou, H
[J]. MOLECULAR PHARMACOLOGY, 2001, 59 (05) : 1277 - 1286
[5] Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors
Enomoto, A
Takeda, M
Shimoda, M
Narikawa, S
Kobayashi, Y
Kobayashi, Y
Yamamoto, T
Sekine, T
Cha, SH
Niwa, T
Endou, H
[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 301 (03) : 797 - 802
[6] Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions
Hasegawa, M
Kusuhara, H
Sugiyama, D
Ito, K
Ueda, S
Endou, H
Sugiyama, Y
[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 300 (03) : 746 - 753
[7] PREVENTIVE EFFECT OF BETAMIPRON ON NEPHROTOXICITY AND UPTAKE OF CARBAPENEMS IN RABBIT RENAL-CORTEX
HIROUCHI, Y
NAGANUMA, H
KAWAHARA, Y
OKADA, R
KAMIYA, A
INUI, K
HORI, R
[J]. JAPANESE JOURNAL OF PHARMACOLOGY, 1994, 66 (01) : 1 - 6
[8] Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: In comparison with rOAT1
Jung, KY
Takeda, M
Shimoda, M
Narikawa, S
Tojo, A
Kim, DK
Chairoungdua, A
Choi, BK
Kusuhara, H
Sugiyama, Y
Sekine, T
Endou, H
[J]. LIFE SCIENCES, 2002, 70 (16) : 1861 - 1874
[9] Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics
Khamdang, S
Takeda, M
Babu, E
Noshiro, R
Onozato, ML
Tojo, A
Enomoto, A
Huang, XL
Narikawa, S
Anzai, N
Piyachaturawat, P
Endou, H
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 465 (1-2) : 1 - 7
[10] Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins
Kimura, H
Takeda, M
Narikawa, S
Enomoto, A
Ichida, K
Endou, H
[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 301 (01) : 293 - 298

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