Investigation of cobalt(III)-triazole systems as prototypes for hypoxia-activated drug delivery

被引：32

作者：

Aguiar de Souza, Isabela Cristina ^{[1
]}

Faro, Leticia Villafranca ^{[1
]}

Pinheiro, Carlos Basilio ^{[2
]}

Gomes Gonzaga, Daniel Tadeu ^{[1
]}

da Silva, Fernando de Carvalho ^{[1
]}

Ferreira, Vitor Francisco ^{[1
]}

Miranda, Fabio da Silva ^{[1
]}

Scarpellini, Marciela ^{[3
]}

Lanznaster, Mauricio ^{[1
]}

机构：

[1] Univ Fed Fluminense, Inst Quim, Outeiro S Joao Batista S-N, BR-24020141 Niteroi, RJ, Brazil

[2] Univ Fed Minas Gerais, Dept Fis, Av Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Fed Rio de Janeiro, Inst Quim, Av Athos da Silveira Ramos 149, BR-21941909 Rio De Janeiro, RJ, Brazil

来源：

DALTON TRANSACTIONS | 2016年 / 45卷 / 35期

关键词：

BIOREDUCTIVE PRODRUGS; COMPLEXES; AGENTS; DERIVATIVES; LIGANDS; DESIGN;

D O I：

10.1039/c6dt02456d

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Three novel cobalt(III)-triazole complexes with structural and redox properties suitable for hypoxia-activated drug delivery were obtained. A major influence of the ancillary ligands (TPA, py(2)en, py(2)enMe(2)) on the electronic properties and reactivity of their complexes was observed. An [O-2]-dependent reduction to cobalt(II) by ascorbic acid provided evidence of hypoxic selectivity.

引用

页码：13671 / 13674

页数：4

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