Supramolecular assembly of poly(β-cyclodextrin) block copolymer and benzimidazole-poly(ε-caprolactone) based on host-guest recognition for drug delivery

被引：34

作者：

Gao, Yurong ^{[1
]}

Li, Guiying ^{[1
]}

Zhou, Zaishuai ^{[1
]}

Guo, Lei ^{[1
]}

Liu, Xunyong ^{[1
]}

机构：

[1] Ludong Univ, Sch Chem & Mat Sci, Yantai 264025, Peoples R China

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2017年 / 160卷

基金：

中国国家自然科学基金;

关键词：

Core-shell complex micelles; Drug release; Host-guest recognition; Poly(beta-cyclodextrin) block copolymer; POLYMERIC MICELLES; BETA-CYCLODEXTRIN; GRAFT COPOLYMER; PH; NANOPARTICLES; VESICLES; CARRIERS; DESIGN;

D O I：

10.1016/j.colsurfb.2017.09.047

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A well-defined double hydrophilic poly(beta-cyclodextrin)-containing diblock copolymer PEG-b-PCD was synthesized by atom transfer radical polymerization (ATRP). Complex micelles with defined core-shell structure were formed based on the host-guest interactions betweenpoly (beta-cyclodextrin) block copolymer and benzimidazole modified poly(epsilon-caprolactone) (BM-PCL). The hydrophobic PCD/BM-PCL resided in the core of micelles, while the hydrophilic poly(ethylene glycol) (PEG) chains acted as the micelles shell. The micelles exhibited regular spheres with diameter of about 255 nm. The drug loading efficiency of micelles for doxorubicin (DOX) was high due to the hydrophobic core containing poly(beta-CD) and PCL. The in vitro release demonstrated that DOX-loaded polymer micelles exhibited an enhanced sustained manner after an initial burst release. The release of drugs was accelerated as the pH reduced from 7.0 to 2.0 and the temperature increased from 25 to 37 degrees C. These results indicate that the complex micelles have potential applications in controlled drug delivery. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：364 / 371

页数：8

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