Entry of nanoparticles into cells: the importance of nanoparticle properties

被引：313

作者：

Zhao, Jiacheng ^{[1
,2
]}

Stenzel, Martina H. ^{[1
,3
]}

机构：

[1] Univ New South Wales, Ctr Adv Macromol Design, Sydney, NSW, Australia

[2] Univ New South Wales, Sch Chem Engn, Sydney, NSW, Australia

[3] Univ New South Wales, Sch Chem, Sydney, NSW, Australia

来源：

POLYMER CHEMISTRY | 2018年 / 9卷 / 03期

基金：

澳大利亚研究理事会;

关键词：

RECEPTOR-MEDIATED ENDOCYTOSIS; ONE-DIMENSIONAL NANOMATERIALS; FLUID-PHASE ENDOCYTOSIS; CELLULAR UPTAKE; IN-VIVO; GOLD NANOPARTICLES; DRUG-DELIVERY; PENETRATING PEPTIDES; CARBON NANOTUBES; INTRACELLULAR TRAFFICKING;

D O I：

10.1039/c7py01603d

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Knowledge of the interactions between nanoparticles (NPs) and cell membranes is of great importance for the design of safe and efficient nanomedicines. Extensive studies aimed at understanding the correlation of NP properties with endocytosis have been carried out in the past few years. Here, we review the recent progress of these studies and provide an overview of the current state of knowledge on the influence of NP size, shape, stiffness and surface chemistry on cellular uptake. Special attention was dedicated to the uptake of non-spherical nanoparticles. Some general principles obtained from these fundamental studies will serve as guidelines for the design of optimised NP for enhanced cellular uptake. Finally, the opportunities for polymer chemists are discussed.

引用

页码：259 / 272

页数：14

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