Oral-ibuprofen-induced acute renal failure in a preterm infant

被引：41

作者：

Erdeve, Omer ^{[1
]}

Sarici, S. Umit ^{[1
]}

Sari, Erkan ^{[1
]}

Gok, Faysal ^{[2
]}

机构：

[1] Gulhane Mil Med Acad, Dept Pediat, Div Neonatol, Ankara, Turkey

[2] Gulhane Mil Med Acad, Dept Pediat, Div Pediat Nephrol, Ankara, Turkey

来源：

PEDIATRIC NEPHROLOGY | 2008年 / 23卷 / 09期

关键词：

ibuprofen; oral; patent ductus arteriosus; renal failure; side effect;

D O I：

10.1007/s00467-008-0835-9

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The side effects of indomethacin for ductal closure in preterm neonates (e.g. increased incidence of necrotizing enterocolitis, decreased cerebral blood volume and transient renal failure) have led clinicians to seek a safer alternative. Intravenous indomethacin and ibuprofen appear to be equally effective for patent ductus arteriosus closure, but oral ibuprofen remains an experimental option with theoretical advantages yet with potential side effects. We herein report a case of transient but severe acute renal failure developing in a preterm infant in whom oral ibuprofen was used and discuss the safety of this drug in relation to its pharmacokinetics.

引用

页码：1565 / 1567

页数：3

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