Drug release from poly(D, L-lactide) SiO2 composites

被引：1

作者：

Vaahtio, M

Jokinen, M

Rosling, A

Kortesuo, P

Kiesvaara, J

Yli-Urpo, A

机构：

[1] Univ Turku, Inst Dent & Biomat Res, FIN-20520 Turku, Finland

[2] Abo Akad Univ, Lab Polymer Technol, FIN-20500 Turku, Finland

[3] Orion Corp Farmos, Orion Pharma, FIN-20101 Turku, Finland

[4] Turku Ctr Biomat, FIN-20520 Turku, Finland

[5] Univ Turku, Inst Dent, Dept Prosthet Dent, FIN-20520 Turku, Finland

来源：

BIOCERAMICS, VOL 16 | 2004年 / 254-2卷

关键词：

drug release; silica gel microparticles; toremifene citrate; poly(D; L-lactide);

D O I：

10.4028/www.scientific.net/KEM.254-256.489

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The aim was to develop a biodegradable carrier system for toremifene citrate based on poly(D,L-lactide) and sol-gel derived SiO2. Two molecular weights of P(D,L-LA) (LMW 130 000 g/mol and HMW 240 000 g/mol) were used in the composites. The release rate of toremifene citrate from P(D,L-LA)/SiO2 composites was evaluated by in vitro dissolution tests. It was shown that it is possible to prepare a controlled release system of toremifene citrate by adding SiO2 particles and/or pores to the used polymer. Release of toremifene citrate can be adjusted from 30 days to 6 months.

引用

页码：489 / 492

页数：4

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