Serum uric acid levels and the risk of Parkinson disease

被引：294
作者：
de Lau, LML
Koudstaal, PJ
Hofman, A
Breteler, MMB
机构：
[1] Erasmus MC, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands
[2] Erasmus MC, Dept Neurol, NL-3000 DR Rotterdam, Netherlands
来源：
ANNALS OF NEUROLOGY | 2005年 / 58卷 / 05期
关键词：
D O I：
10.1002/ana.20663
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In a prospective population-based cohort study among 4,695 participants aged 55 years and older, with repeated in-person examination and on average 9.4 years of follow-up, we observed that higher serum levels of uric acid were associated with a significantly decreased risk of Parkinson disease (adjusted hazard ratio per standard deviation increase 0.71 [95% confidence interval 0.51-0.98]), with evidence for a dose-effcct relationship (p value for trend over quartiles 0.040). Our findings support the hypothesis that oxidative stress contributes to the risk of Parkinson disease and suggest a potential protective effect of the natural antioxidant and free radical scavenger uric acid.
引用
收藏
页码：797 / 800
页数：4
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