In-vitro cell tests using doxorubicin-loaded polymeric TiO2 nanotubes used for cancer photothermotherapy

被引:5
作者
Hong, Chanseok [1 ]
An, Soyeon [1 ]
Son, Mikwon [2 ]
Hong, Soon Sun [2 ]
Lee, Don Haeng [2 ]
Lee, Chongmu [1 ]
机构
[1] Inha Univ, Dept Mat Sci & Engn, Inchon, South Korea
[2] Inha Univ, Coll Med, Inchon, South Korea
关键词
antibody; near-infrared light; photothermotherapy; surfactant; TiO2; nanotubes; THERAPEUTIC AGENT; TITANIUM; NANOPARTICLES; BEHAVIOR; LIGHT;
D O I
10.1097/CAD.0b013e328350446b
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
To determine the appropriate surfactant to be added to TiO2 nanotubes (TNTs) for use in cancer photothermotherapy, this study measured the increase in temperature and examined the size distribution of TNT particles loaded with different surfactants during near-infrared irradiation. In addition, in-vitro cell (fluorescein isothiocyanate and MTT assay) tests were carried out to examine the cytotoxic effect of doxorubicin-loaded and polyvinyl alcohol-added TNTs (pTNTs). The mean particle size of the pTNTs was 151.8 nm with a particle size variation of less than 3 nm, which is low enough to flow through blood vessels without causing a blockage. The temperature of the pTNTs was similar to 47 degrees C, which is high enough to destroy cancer cells. Doxorubicin-loaded TNTs and pTNTs in combination with a near-infrared laser showed a cell viability of 4.5% - a sufficiently high cytotoxic effect. Anti-Cancer Drugs 23:553-560 (C) 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.
引用
收藏
页码:553 / 560
页数:8
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