Molecular Choreography of Acute Exercise

被引：334

作者：

Contrepois, Kevin ^{[1
,2
]}

Wu, Si ^{[1
]}

Moneghetti, Kegan J. ^{[2
,3
,4
,5
]}

Hornburg, Daniel ^{[1
]}

Ahadi, Sara ^{[1
]}

Tsai, Ming-Shian ^{[1
]}

Metwally, Ahmed A. ^{[1
]}

Wei, Eric ^{[1
]}

Lee-McMullen, Brittany ^{[1
]}

Quijada, Jeniffer, V ^{[1
]}

Chen, Songjie ^{[1
]}

Christle, Jeffrey W. ^{[2
,3
,5
]}

Ellenberger, Mathew ^{[1
]}

Balliu, Brunilda ^{[6
]}

Taylor, Shalina ^{[7
]}

Durrant, Matthew G. ^{[1
]}

Knowles, David A. ^{[1
,8
]}

Choudhry, Hani ^{[9
]}

Ashland, Melanie ^{[1
]}

Bahmani, Amir ^{[1
]}

Enslen, Brooke ^{[1
]}

Amsallem, Myriam ^{[2
,3
]}

Kobayashi, Yukari ^{[2
,3
]}

Avina, Monika ^{[1
]}

Perelman, Dalia ^{[1
]}

Rose, Sophia Miryam Schussler-Fiorenza ^{[1
]}

Zhou, Wenyu ^{[1
]}

Ashley, Euan A. ^{[1
,3
,10
]}

Montgomery, Stephen B. ^{[1
,6
]}

Chaib, Hassan ^{[1
]}

Haddad, Francois ^{[2
,3
,11
]}

Snyder, Michael P. ^{[1
,2
,11
]}

机构：

[1] Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA

[3] Stanford Univ, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA

[4] Univ Melbourne, St Vincents Hosp, Dept Med, Melbourne, Vic, Australia

[5] Stanford Univ, Dept Med, Stanford Sports Cardiol, Stanford, CA 94305 USA

[6] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA

[7] Stanford Univ, Pediat Dept, Sch Med, Stanford, CA 94305 USA

[8] Stanford Univ, Dept Radiol, Stanford, CA 94305 USA

[9] King Abdulaziz Univ, Canc & Mutagenesis Unit, King Fahd Ctr Med Res, Fac Sci,Dept Biochem, Jeddah, Saudi Arabia

[10] Stanford Univ, Ctr Undiagnosed Dis, Stanford, CA 94305 USA

[11] Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA

来源：

CELL | 2020年 / 181卷 / 05期

关键词：

BLOOD MONONUCLEAR-CELLS; CORONARY-HEART-DISEASE; LEAN BODY-MASS; SKELETAL-MUSCLE; GENE-EXPRESSION; ADHESION MOLECULES; AEROBIC CAPACITY; MAXIMAL EXERCISE; FITNESS REGISTRY; ARTERY CALCIUM;

D O I：

10.1016/j.cell.2020.04.043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acute physical activity leads to several changes in metabolic, cardiovascular, and immune pathways. Although studies have examined selected changes in these pathways, the system-wide molecular response to an acute bout of exercise has not been fully characterized. We performed longitudinal multi- omic profiling of plasma and peripheral blood mononuclear cells including metabolome, lipidome, immunome, proteome, and transcriptome from 36 well-characterized volunteers, before and after a controlled bout of symptomlimited exercise. Time-series analysis revealed thousands of molecular changes and an orchestrated choreography of biological processes involving energy metabolism, oxidative stress, inflammation, tissue repair, and growth factor response, as well as regulatory pathways. Most of these processes were dampened and some were reversed in insulin-resistant participants. Finally, we discovered biological pathways involved in cardiopulmonary exercise response and developed prediction models revealing potential resting bloodbased biomarkers of peak oxygen consumption.

引用

页码：1112 / +

页数：35

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