Polyphenols as potential inhibitors of amyloid aggregation and toxicity: Possible significance to Alzheimer's disease

被引：71
|
作者：
Bastianetto, S. [1 ]
Krantic, S. [2 ]
Quirion, R. [1 ]
机构：
[1] McGill Univ, Dept Psychiat, Douglas Mental Hlth Univ Inst, Verdun, PQ H4H 1R3, Canada
[2] INSERM, F-13273 Marseille, France
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 05期
关键词：
Alzheimer's disease; polyphenols; neuroprotection;
D O I：
10.2174/138955708784223512
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Beta-amyloid (A likely plays a pivotal role in the etiology of Alzheimer's disease (AD). Consequently, A associated pathways are targets for the development of possible effective AD therapies. This review first updates strategies aimed at the inhibition of A formation and then discusses the role of food-derived polyphenols as putative anti-amyloid drugs.
引用
收藏
页码：429 / 435
页数：7
相关论文
共 50 条
  • [41] The Early Events That Initiate β-Amyloid Aggregation in Alzheimer's Disease
    Zhang, Xingyu
    Fu, Zhihui
    Meng, Lanxia
    He, Mingyang
    Zhang, Zhentao
    FRONTIERS IN AGING NEUROSCIENCE, 2018, 10
  • [42] Alkannin Attenuates Amyloid ? Aggregation and Alzheimer?s Disease Pathology
    Hosoi, Toru
    Yazawa, Kyosuke
    Imada, Michihiro
    Tawara, Akari
    Tohda, Chihiro
    Nomura, Yasuyuki
    Ozawa, Koichiro
    MOLECULAR PHARMACOLOGY, 2023, 103 (05) : 266 - 273
  • [43] A qualitative model for aggregation and diffusion of β-amyloid in Alzheimer's disease
    Achdou, Yves
    Franchi, Bruno
    Marcello, Norina
    Tesi, Maria Carla
    JOURNAL OF MATHEMATICAL BIOLOGY, 2013, 67 (6-7) : 1369 - 1392
  • [44] Copper in Alzheimer's disease: Implications in amyloid aggregation and neurotoxicity
    Gamez, Patrick
    Caballero, Ana B.
    AIP ADVANCES, 2015, 5 (09):
  • [45] Assessment of Novel Curcumin Derivatives as Potent Inhibitors of Inflammation and Amyloid-β Aggregation in Alzheimer's Disease
    Lakey-Beitia, Johant
    Gonzalez, Yisett
    Doens, Deborah
    Stephens, David E.
    Santamaria, Ricardo
    Murillo, Enrique
    Gutierrez, Marcelino
    Fernandez, Patricia L.
    Rao, K. S.
    Larionov, Oleg V.
    Durant-Archibold, Armando A.
    JOURNAL OF ALZHEIMERS DISEASE, 2017, 60 : S59 - S68
  • [46] Development of Tau Aggregation Inhibitors for Alzheimer's Disease
    Bulic, Bruno
    Pickhardt, Marcus
    Schmidt, Boris
    Mandelkow, Eva-Maria
    Waldmann, Herbert
    Mandelkow, Eckhard
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (10) : 1741 - 1752
  • [47] Recent advances in the design and applications of amyloid-β peptide aggregation inhibitors for Alzheimer’s disease therapy
    Jokar S.
    Khazaei S.
    Behnammanesh H.
    Shamloo A.
    Erfani M.
    Beiki D.
    Bavi O.
    Biophysical Reviews, 2019, 11 (6) : 901 - 925
  • [48] Carbon dots as dual inhibitors of tau and amyloid-beta aggregation for the treatment of Alzheimer's disease
    Zhang, Wei
    Smith, Nathan
    Zhou, Yiqun
    McGee, Caitlin M.
    Bartoli, Mattia
    Fu, Shiwei
    Chen, Jiuyan
    Domena, Justin B.
    Joji, Annu
    Burr, Hannah
    Lv, Guohua
    Cilingir, Emel K.
    Bedendo, Susanna
    Claure, Matteo L.
    Tagliaferro, Alberto
    Eliezer, David
    Veliz, Eduardo A.
    Zhang, Fuwu
    Wang, Chunyu
    Leblanc, Roger M.
    ACTA BIOMATERIALIA, 2024, 183 : 341 - 355
  • [49] Designing peptide inhibitors for oligomerization and toxicity of Alzheimer's β-amyloid peptide
    Austen, Brian M.
    Paleologou, Katerina E.
    Ali, Sumaya A. E.
    Qureshi, Mohamed M.
    Allsop, David
    El-Agnaf, Omar M. A.
    BIOCHEMISTRY, 2008, 47 (07) : 1984 - 1992
  • [50] Native PLGA nanoparticles regulate APP metabolism and protect neurons against ?-amyloid toxicity: Potential significance in Alzheimer's disease pathology
    Wu, Qi
    Karthivashan, Govindarajan
    Nakhaei-Nejad, Maryam
    Anand, Bibin G.
    Giuliani, Fabrizio
    Kar, Satyabrata
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 219 : 1180 - 1196
12345