Polyphenols as potential inhibitors of amyloid aggregation and toxicity: Possible significance to Alzheimer's disease

被引：71
作者：
Bastianetto, S. [1 ]
Krantic, S. [2 ]
Quirion, R. [1 ]
机构：
[1] McGill Univ, Dept Psychiat, Douglas Mental Hlth Univ Inst, Verdun, PQ H4H 1R3, Canada
[2] INSERM, F-13273 Marseille, France
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 05期
关键词：
Alzheimer's disease; polyphenols; neuroprotection;
D O I：
10.2174/138955708784223512
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Beta-amyloid (A likely plays a pivotal role in the etiology of Alzheimer's disease (AD). Consequently, A associated pathways are targets for the development of possible effective AD therapies. This review first updates strategies aimed at the inhibition of A formation and then discusses the role of food-derived polyphenols as putative anti-amyloid drugs.
引用
收藏
页码：429 / 435
页数：7
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